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- W3148142783 abstract "Objective To investigate the changes on protein kinase C (PKC) activity of alveolar macrophages (AMs) in patients with idiopathic pulmonary fibrosis (IPF) Methods The PKC activity of AM in 9 healthy volunteers and 15 patients with IPF was investigated by measuring the radioactivity Results The total, cytosolic and membrane PKC activity of AM in bronchoalveolar lavage fluid (BALF) from patients with IPF were higher than those from control group ( P 0 01, P 0 05 and P 0 05, respectively) The total and the membrane associated PKC activity had a positive correlation with the number of cells in BALF ( r =0 8135, P 0 01 and r =0 5917, P 0 05), respectively Conclusion As a bypass of transmembrane signal transduction, PKC was suggested to be involved in the origination and development of IPF" @default.
- W3148142783 created "2021-04-13" @default.
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- W3148142783 date "2001-01-01" @default.
- W3148142783 modified "2023-09-25" @default.
- W3148142783 title "Increased activity of protein kinase C in alveolar macrophages in idiopathic pulmonary fibrosis" @default.
- W3148142783 hasPublicationYear "2001" @default.
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