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- W3148157445 abstract "The developmental stage-specific silencing of the human e-globin gene during embryonic life is controlled, inpart, by the silencer (-392bp～-177bp) upstream of thisgene. In order to elucidate its role, the nuclear extractfrom the human fetal liver has been prepared and the interactions between trans-acting factors and this silencerelement have been examined. By using DNasel footprinting assay, a major protected region from -278bp to -235bpwithin this silencer element was identified. Furthermore,we found in gel mobility shift assay and Southwestern blotting assay that there were at least four trans-acting factors (MW ≈ 32, 28, 26 and 22kD) in the nuclear extractisolated from the human fetal liver, which could specifically bind to this region. Our results suggested that thesetrans-acting factors might play an important role in silencing the human embryonic e-globin gene expression at thefetal stage through the interactions with this silencer." @default.
- W3148157445 created "2021-04-13" @default.
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- W3148157445 date "1997-01-01" @default.
- W3148157445 modified "2023-09-25" @default.
- W3148157445 title "Trans-acting factors from the human fetal liver bindingto the human ε-globin gene silencer" @default.
- W3148157445 hasPublicationYear "1997" @default.
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