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- W3148163043 abstract "Introduction: Depletion of cellular pool and constant activation of plasmacytoid dendritic cells (pDCs) in HIV-infected persons (HIV ) are associated with disease progression and manifestation of opportunistic infections. The influence of highly-active antiretroviral treatment (HAART) and suppressed HCV-co-infection (HIV /HCV ) on the extent of these changes remains unknown. Objective: To study parameters of pDCs in peripheral blood of HIV and HIV /HCV patients on HAART. Methods: Twelve uninfected with HIV or HCV volunteers and 37 patients (12 HIV , 9 HIV /HCV and 16 HCV ) were enrolled. All HIV patients received HAART and had undetermined HIV viral load. All HCV patients had finished antiviral therapy (Pegasys/ribavirin) with sustained viral response for six months and more. The pDC population was enumerated by flow cytometry. In vitro IFN production in the whole blood in response to pDC-specific stimulus unmethylated CpG oligonucleotides was determined by enzyme-linked immunosorbent assay (ELISA). Results: The percentage of pDCs of peripheral blood mononuclear cells (PBMC) in HIV /HCV was the lowest (0.0890.02) but statistically not different from HIV (0.1590.03; p 0.11) and significantly lower than HCV (0.1790.015; p 0.4) and controls (0.2790.045; p 0.03). Absolute number of pDCs in HIV on HAART (6.391.3) was not significantly lower than the control (10.2591.75; p 0.09) but in HIV /HCV (5.191.2; p 0.03), the difference was valid. IFN-alpha production by pDCs in patients on HAART in HIV (2.490.9 pg/ml) and in HIV /HCV (3.791 pg/ml) patients were significantly higher than in controls (in controls IFN-alpha production by pDCs in the native plasma was below the level of detection (3 pg/ml), p 0.02 and p 0.0014). Conclusions: Absolute number of pDC in HIV-positive person on HAART with sustained viral response to treatment of HCV-coinfection was lower than in HIV-mono-infected. IFN-alpha production by pDC in HIV and in HIV /HCV patients receiving HAART remains higher than in uninfected persons." @default.
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- W3148163043 date "2014-01-01" @default.
- W3148163043 modified "2023-09-24" @default.
- W3148163043 title "Plasmacytoid Dendritic cells (pDCs) in HIV-infected and HIV/HCV-co-infected patients receiving successful treatment" @default.
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