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- W3148251366 abstract "The p53 protein is an important tumor suppressor that modulates many physiological activities of the cell and maintains the stability and integrity of the genome.p53 is located at the center of a complicated signaling network.The p53 network can respond to a wide variety of stress including DNA damage,oncogene activation and telomere erosion.Depending on the severity of DNA damage,p53 may induce DNA repair/cell cycle arrest,senescence,or apoptosis to avoid the replication and propagation of the genomic defects to daughter cells.The concentration of p53 exhibits several types of dynamics such as pulsatile and switch-like behaviors.There exist rich nonlinear properties in the p53 dynamics.In this review,we focus on the latest progress in the field of p53 dynamics,and clarify the underlying connection between p53 dynamics and its biological functions in the DNA damage response." @default.
- W3148251366 created "2021-04-13" @default.
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- W3148251366 date "2014-01-01" @default.
- W3148251366 modified "2023-09-23" @default.
- W3148251366 title "Nonlinear dynamics in the p53 signaling network" @default.
- W3148251366 hasPublicationYear "2014" @default.
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