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- W3148275836 abstract "Podoplanin (PDPN ) 是在多样的房间类型表示的粘蛋白类型 O-glycoprotein，例如在脉管的系统和 fibroblastic 的淋巴的 endothelial 房间(LEC ) 在淋巴节点的网状的房间(FRC ) 。LEC 或 FRC 上的 PDPN 在血小板激活 CLEC-2，触发通过下游地表明事件的血小板激活或聚集，包括 Syk kinase 的激活。这机制被要求开始并且维持血和淋巴管的分离并且在淋巴节点以内稳定高 endothelial 小静脉正直。在脉管的系统，在 LEC 表面的 PDPN 的正常表示与核心 1-derived O-glycans 由 PDPN 的 Prox1 和修正要求 Pdpn 的 transcriptional 激活。这评论在脉管的开发和淋巴的机关维护提供 PDPN 的角色的全面概述并且讨论调整与它的函数有关的 PDPN 表示的机制。" @default.
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- W3148275836 date "2015-01-01" @default.
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- W3148275836 title "Emerging roles of podoplanin in vascular development and homeostasis" @default.
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