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• W3148284984 abstract "Observational studies suggest that rheumatoid arthritis (RA) may be associated with lung cancer (LC) risk, while the evidence is inconsistent. We conducted a meta-analysis and a Mendelian randomization study to investigate the association and causality between RA and the LC risk. We conducted a systematic search of cohort studies and performed a meta-analysis (PROSPERO ID CRD42020159082) to calculate the relative risks (RRs) and their 95% confidence intervals (95%CIs). Subgroup analyses based on sex and initiation year of follow-up were carried out. E‐values of each study were calculated to evaluate if existing studies were sensitive to unmeasured confounding. Furthermore, we investigated the correlation between genetically predisposed RA and LC risk using summary statistics from the International Lung Cancer Consortium (11,348 cases and 15,861 controls) and 90 RA-related single nucleotide polymorphisms from European and East Asian descent as instrumental variables. A two-sample Mendelian randomization (MR) analysis was performed to detect the findings based on LC and histological subtypes. Sensitivity analyses were performed to test the robustness of our findings. In the meta-analysis of 11 cohort studies involving 183,888 patients, an increased risk of LC was observed among RA patients (RR = 1.44, 95%CI = 1.31–1.57). Subgroup analyses suggested that male patients have a relatively higher LC risk than female patients, and an increased incidence of LC in RA patients was found from 1950 to 2010. Conversely, in the MR analysis, we found that genetically predisposed RA was associated with a decreased risk of LC overall, while neither causally associated with the risk of lung adenocarcinoma nor squamous cell lung cancer. Nevertheless, genetically predisposed RA was associated with a decreased LC risk among the East Asian population, but not in Europeans. These results were robust against extensive sensitivity analyses. Our meta-analysis suggested that although RA was associated with a relatively higher LC risk, the causal relationship between genetically predisposed RA and LC risk was not supported by the MR study. Further studies are warranted to elucidate the possible association between RA and the risk of LC, as well as its underlying mechanisms." @default.
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• W3148284984 date "2021-06-01" @default.
• W3148284984 modified "2023-10-10" @default.
• W3148284984 title "Rheumatoid arthritis and risk of lung cancer: Meta-analysis and Mendelian randomization study" @default.
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• W3148284984 cites W1977434336 @default.
• W3148284984 cites W1978506898 @default.
• W3148284984 cites W1979423827 @default.
• W3148284984 cites W1980827798 @default.
• W3148284984 cites W1989574614 @default.
• W3148284984 cites W1989590412 @default.
• W3148284984 cites W1991891486 @default.
• W3148284984 cites W1996715439 @default.
• W3148284984 cites W1998716086 @default.
• W3148284984 cites W2005180147 @default.
• W3148284984 cites W2013474471 @default.
• W3148284984 cites W2017116566 @default.
• W3148284984 cites W2022441502 @default.
• W3148284984 cites W2025001196 @default.
• W3148284984 cites W2025694141 @default.
• W3148284984 cites W2033366171 @default.
• W3148284984 cites W2040695321 @default.
• W3148284984 cites W2050142463 @default.
• W3148284984 cites W2069954767 @default.
• W3148284984 cites W2071099746 @default.
• W3148284984 cites W2081107208 @default.
• W3148284984 cites W2083832226 @default.
• W3148284984 cites W2085799069 @default.
• W3148284984 cites W2100382163 @default.
• W3148284984 cites W2104388056 @default.
• W3148284984 cites W2104669609 @default.
• W3148284984 cites W2113699335 @default.
• W3148284984 cites W2115692737 @default.
• W3148284984 cites W2115783720 @default.
• W3148284984 cites W2117335168 @default.
• W3148284984 cites W2127817571 @default.
• W3148284984 cites W2132576596 @default.
• W3148284984 cites W2155533485 @default.
• W3148284984 cites W2159274727 @default.
• W3148284984 cites W2164738490 @default.
• W3148284984 cites W2172368692 @default.
• W3148284984 cites W2197347269 @default.
• W3148284984 cites W2198755677 @default.
• W3148284984 cites W2265865881 @default.
• W3148284984 cites W2324862792 @default.
• W3148284984 cites W2325761966 @default.
• W3148284984 cites W2411555633 @default.
• W3148284984 cites W2518077791 @default.
• W3148284984 cites W2572655490 @default.
• W3148284984 cites W2588675203 @default.
• W3148284984 cites W2620908531 @default.
• W3148284984 cites W2735301415 @default.
• W3148284984 cites W2800956141 @default.
• W3148284984 cites W2801697966 @default.
• W3148284984 cites W2805983714 @default.
• W3148284984 cites W2806460375 @default.
• W3148284984 cites W2807800408 @default.
• W3148284984 cites W2810560584 @default.
• W3148284984 cites W2811185887 @default.
• W3148284984 cites W2811337898 @default.
• W3148284984 cites W2910163465 @default.
• W3148284984 cites W2953121869 @default.
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• W3148284984 doi "https://doi.org/10.1016/j.semarthrit.2021.03.015" @default.
• W3148284984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33932788" @default.
• W3148284984 hasPublicationYear "2021" @default.
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