FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148291238> ?p ?o ?g. }

• W3148291238 endingPage "638" @default.
• W3148291238 startingPage "633" @default.
• W3148291238 abstract "IL-31 is a major pruritogen associated with atopic dermatitis (AD). Although a specific antibody for IL-31 receptor has been shown to alleviate pruritus in patients with AD, therapeutic approaches to inhibition of IL-31 production remain unexploited. IL-31 production by TH cells critically depends on the transcription factor EPAS1, which mediates IL31 promoter activation in collaboration with SP1.We aimed at developing small-molecule inhibitors that selectively block IL-31 production by TH cells.We generated the reporter cell line that inducibly expressed EPAS1 in the presence of doxycycline to mediate Il31 promoter activation, and we screened 9600 chemical compounds. The selected compounds were further examined by using TH cells from a spontaneous mouse model of AD and TH cells from patients with AD.We have identified 4-(2-(4-isopropylbenzylidene)hydrazineyl)benzoic acid (IPHBA) as an inhibitor of IL31 induction. Although IPHBA did not affect nonspecific T-cell proliferation, IPHBA inhibited antigen-induced IL-31 production by TH cells from both an AD mouse model and patients with AD without affecting other cytokine production and hypoxic responses. In line with this, itch responses induced by adoptive transfer of IL-31-producing TH cells were attenuated when mice were orally treated with IPHBA. Mechanistically, IPHBA inhibited the association between EPAS1 and SP1, resulting in defective recruitment of both transcription factors to the specific sites of the IL31 promoter. We also determined the structure-activity relationship of IPHBA by synthesizing and analyzing 201 analogous compounds.IPHBA could be a potential drug leading to inhibition of EPAS1-driven IL-31 production." @default.
• W3148291238 created "2021-04-13" @default.
• W3148291238 creator A5021992437 @default.
• W3148291238 creator A5022383913 @default.
• W3148291238 creator A5030952055 @default.
• W3148291238 creator A5038100809 @default.
• W3148291238 creator A5043225877 @default.
• W3148291238 creator A5055983625 @default.
• W3148291238 creator A5057230322 @default.
• W3148291238 creator A5057612352 @default.
• W3148291238 creator A5063649274 @default.
• W3148291238 creator A5067303784 @default.
• W3148291238 creator A5073571274 @default.
• W3148291238 creator A5083867472 @default.
• W3148291238 creator A5085142320 @default.
• W3148291238 creator A5088288669 @default.
• W3148291238 date "2021-08-01" @default.
• W3148291238 modified "2023-09-30" @default.
• W3148291238 title "Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound" @default.
• W3148291238 cites W1929032511 @default.
• W3148291238 cites W2021520444 @default.
• W3148291238 cites W2036511906 @default.
• W3148291238 cites W2050291872 @default.
• W3148291238 cites W2077529892 @default.
• W3148291238 cites W2087377825 @default.
• W3148291238 cites W2095224028 @default.
• W3148291238 cites W2102476325 @default.
• W3148291238 cites W2142127956 @default.
• W3148291238 cites W2147889176 @default.
• W3148291238 cites W2567925589 @default.
• W3148291238 cites W2593200577 @default.
• W3148291238 cites W2732263256 @default.
• W3148291238 cites W2767394258 @default.
• W3148291238 cites W2802146778 @default.
• W3148291238 cites W2901273371 @default.
• W3148291238 cites W3014570039 @default.
• W3148291238 cites W3037568344 @default.
• W3148291238 cites W3043752214 @default.
• W3148291238 cites W4211026773 @default.
• W3148291238 cites W4233073010 @default.
• W3148291238 doi "https://doi.org/10.1016/j.jaci.2021.03.029" @default.
• W3148291238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33819507" @default.
• W3148291238 hasPublicationYear "2021" @default.
• W3148291238 type Work @default.
• W3148291238 sameAs 3148291238 @default.
• W3148291238 citedByCount "4" @default.
• W3148291238 countsByYear W31482912382021 @default.
• W3148291238 countsByYear W31482912382022 @default.
• W3148291238 countsByYear W31482912382023 @default.
• W3148291238 crossrefType "journal-article" @default.
• W3148291238 hasAuthorship W3148291238A5021992437 @default.
• W3148291238 hasAuthorship W3148291238A5022383913 @default.
• W3148291238 hasAuthorship W3148291238A5030952055 @default.
• W3148291238 hasAuthorship W3148291238A5038100809 @default.
• W3148291238 hasAuthorship W3148291238A5043225877 @default.
• W3148291238 hasAuthorship W3148291238A5055983625 @default.
• W3148291238 hasAuthorship W3148291238A5057230322 @default.
• W3148291238 hasAuthorship W3148291238A5057612352 @default.
• W3148291238 hasAuthorship W3148291238A5063649274 @default.
• W3148291238 hasAuthorship W3148291238A5067303784 @default.
• W3148291238 hasAuthorship W3148291238A5073571274 @default.
• W3148291238 hasAuthorship W3148291238A5083867472 @default.
• W3148291238 hasAuthorship W3148291238A5085142320 @default.
• W3148291238 hasAuthorship W3148291238A5088288669 @default.
• W3148291238 hasBestOaLocation W31482912382 @default.
• W3148291238 hasConcept C104317684 @default.
• W3148291238 hasConcept C153911025 @default.
• W3148291238 hasConcept C170493617 @default.
• W3148291238 hasConcept C185592680 @default.
• W3148291238 hasConcept C203014093 @default.
• W3148291238 hasConcept C2776090121 @default.
• W3148291238 hasConcept C2778690821 @default.
• W3148291238 hasConcept C502942594 @default.
• W3148291238 hasConcept C54355233 @default.
• W3148291238 hasConcept C55493867 @default.
• W3148291238 hasConcept C81885089 @default.
• W3148291238 hasConcept C86339819 @default.
• W3148291238 hasConcept C86803240 @default.
• W3148291238 hasConcept C8891405 @default.
• W3148291238 hasConcept C90375314 @default.
• W3148291238 hasConcept C95444343 @default.
• W3148291238 hasConceptScore W3148291238C104317684 @default.
• W3148291238 hasConceptScore W3148291238C153911025 @default.
• W3148291238 hasConceptScore W3148291238C170493617 @default.
• W3148291238 hasConceptScore W3148291238C185592680 @default.
• W3148291238 hasConceptScore W3148291238C203014093 @default.
• W3148291238 hasConceptScore W3148291238C2776090121 @default.
• W3148291238 hasConceptScore W3148291238C2778690821 @default.
• W3148291238 hasConceptScore W3148291238C502942594 @default.
• W3148291238 hasConceptScore W3148291238C54355233 @default.
• W3148291238 hasConceptScore W3148291238C55493867 @default.
• W3148291238 hasConceptScore W3148291238C81885089 @default.
• W3148291238 hasConceptScore W3148291238C86339819 @default.
• W3148291238 hasConceptScore W3148291238C86803240 @default.
• W3148291238 hasConceptScore W3148291238C8891405 @default.
• W3148291238 hasConceptScore W3148291238C90375314 @default.
• W3148291238 hasConceptScore W3148291238C95444343 @default.
• W3148291238 hasFunder F4320311405 @default.

• next