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- W3148307525 abstract "染色质结构充分为控制基因表示是重要的，但是位于染色质改变下面的机制不是理解。这里，我们报导 FKBP (FK506 有约束力的蛋白质) 打 immunophilin， AtFKBP53，拥有 histone 女伴活动并且为镇压被要求在 Arabidopsis 的 ribosomal 基因表示。AtFKBP53 蛋白质是有典型 peptidylprolyl isomerase (PPIase ) 的 multidomain FKBP 领域和几个高度控告的领域。用 nucleosome 汇编试金，我们证明 AtFKBP53 举办 histone 女伴活动，控告的酸的域为这项活动是足够的。我们证明 AtFKBP53 通过酸的领域与 histone H3 交往，而 PPIase 领域为 histone 女伴活动或 histone 绑定是非必需的。当 AtFKBP53 活动在 Arabidopsis 被减少或消除植物时， Ribosomal RNA 基因(18S rDNA ) 是 overexpressed。染色质 immunoprecipitation 试金证明 AtFKBP53 与 18S rDNA 基因染色质被联系，含有 AtFKBP53 镇压在染色质水平的 rRNA 基因。这研究在在染色质改变和抄写的规定工作的植物识别新 histone 女伴。" @default.
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- W3148307525 date "2010-01-01" @default.
- W3148307525 modified "2023-10-17" @default.
- W3148307525 title "AtFKBP53 is a histone chaperone required for repression of ribosomal RNA gene expression in Arabidopsis" @default.
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