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- W3148317237 abstract "The incorporation of carbon-14 allows tracking of organic molecules and provides vital knowledge on their fate. This information is critical in pharmaceutical development, crop science, and human food safety evaluation. Herein, a transition-metal-catalyzed procedure enabling carbon isotope exchange on aromatic nitriles is described. By utilizing the radiolabeled precursor Zn([14C]CN)2, this protocol allows the insertion of the desired carbon tag without the need for structural modifications, in a single step. By reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the labeling of nitrile containing drugs and accelerate 14C-based ADME studies supporting drug development." @default.
- W3148317237 created "2021-04-13" @default.
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- W3148317237 date "2021-04-07" @default.
- W3148317237 modified "2023-10-16" @default.
- W3148317237 title "Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation" @default.
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- W3148317237 doi "https://doi.org/10.1021/jacs.1c01923" @default.
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