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- W3148321796 endingPage "108921" @default.
- W3148321796 startingPage "108921" @default.
- W3148321796 abstract "The breast cancer type I susceptibility protein (BRCA1) and BRCA1-associated RING domain protein I (BARD1) heterodimer promote genome integrity through pleiotropic functions, including DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1-BARD1 heterodimerization is required for their mutual stability, HR function, and role in tumor suppression; however, the upstream signaling events governing BRCA1-BARD1 heterodimerization are unclear. Here, we show that SIRT2, a sirtuin deacetylase and breast tumor suppressor, promotes BRCA1-BARD1 heterodimerization through deacetylation. SIRT2 complexes with BRCA1-BARD1 and deacetylates conserved lysines in the BARD1 RING domain, interfacing BRCA1, which promotes BRCA1-BARD1 heterodimerization and consequently BRCA1-BARD1 stability, nuclear retention, and localization to DNA damage sites, thus contributing to efficient HR. Our findings define a mechanism for regulation of BRCA1-BARD1 heterodimerization through SIRT2 deacetylation, elucidating a critical upstream signaling event directing BRCA1-BARD1 heterodimerization, which facilitates HR and tumor suppression, and delineating a role for SIRT2 in directing DSB repair by HR." @default.
- W3148321796 created "2021-04-13" @default.
- W3148321796 creator A5001085971 @default.
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- W3148321796 creator A5067547603 @default.
- W3148321796 date "2021-03-01" @default.
- W3148321796 modified "2023-10-12" @default.
- W3148321796 title "SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation" @default.
- W3148321796 cites W1714818982 @default.
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- W3148321796 cites W1969807455 @default.
- W3148321796 cites W1972103684 @default.
- W3148321796 cites W1979681327 @default.
- W3148321796 cites W1980438294 @default.
- W3148321796 cites W1981549228 @default.
- W3148321796 cites W1984431444 @default.
- W3148321796 cites W1985531090 @default.
- W3148321796 cites W1987605482 @default.
- W3148321796 cites W1989996784 @default.
- W3148321796 cites W1995987769 @default.
- W3148321796 cites W1996395636 @default.
- W3148321796 cites W1998974491 @default.
- W3148321796 cites W2004935367 @default.
- W3148321796 cites W2010369105 @default.
- W3148321796 cites W2012675953 @default.
- W3148321796 cites W2014975526 @default.
- W3148321796 cites W2016042605 @default.
- W3148321796 cites W2016406151 @default.
- W3148321796 cites W2017714068 @default.
- W3148321796 cites W2021798973 @default.
- W3148321796 cites W2032679606 @default.
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- W3148321796 cites W2039435798 @default.
- W3148321796 cites W2040462263 @default.
- W3148321796 cites W2041020776 @default.
- W3148321796 cites W2044784487 @default.
- W3148321796 cites W2047368106 @default.
- W3148321796 cites W2059365987 @default.
- W3148321796 cites W2064681322 @default.
- W3148321796 cites W2066108933 @default.
- W3148321796 cites W2067818013 @default.
- W3148321796 cites W2068638854 @default.
- W3148321796 cites W2071411482 @default.
- W3148321796 cites W2073193520 @default.
- W3148321796 cites W2075976137 @default.
- W3148321796 cites W2081027578 @default.
- W3148321796 cites W2081036514 @default.
- W3148321796 cites W2086840280 @default.
- W3148321796 cites W2088179903 @default.
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- W3148321796 cites W2168225429 @default.
- W3148321796 cites W2168702014 @default.
- W3148321796 cites W2169262415 @default.
- W3148321796 cites W2202793640 @default.
- W3148321796 cites W2271661412 @default.
- W3148321796 cites W2312699414 @default.
- W3148321796 cites W2346024122 @default.
- W3148321796 cites W2577344516 @default.
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- W3148321796 doi "https://doi.org/10.1016/j.celrep.2021.108921" @default.
- W3148321796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8108010" @default.
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- W3148321796 hasPublicationYear "2021" @default.
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