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• W3148333815 abstract "Pathogenesis of autoimmune subepidermal bullous diseases, which include bullous pemphigoid (BP) and dermatitis herpetiformis (DH), is associated with destruction of basement membrane components, leading to formation of bullae. Basement membrane is a complex structure providing integrity of dermo-epidermal junction. Antibodies binding to autoantigens localized in the basement membrane activate a series of immunological and enzymatic phenomena that lead to destruction of anchoring fibers. Pemphigoid is a bullous dermatosis characterized by inflammatory infiltrate in the dermis and deposits of IgG immunoglobulin and C3 component of the complement alongside the basement membrane of the epidermis. Their presence may be revealed by direct immunofluorescence test (DIF), which has diagnostic importance for the disease. Ultrastructural studies confirm the presence of intensive inflammatory infiltrate at the dermo-epidermal junction, as well as destruction of hemidesmosomes and components of The role of adamalysins (ADAMs) in destruction of anchoring fibers involved in pathogenesis of selected subepidermal bullous diseases" @default.
• W3148333815 created "2021-04-13" @default.
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• W3148333815 date "2006-01-01" @default.
• W3148333815 modified "2023-09-25" @default.
• W3148333815 title "The role of adamalysins (ADAMs) in destruction of anchoring fibers involved in pathogenesis of selected subepidermal bullous diseases" @default.
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