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- W3148334212 abstract "提高并且延长结缔组织生长因素(CTGF ) 的表示的背景与肾纤维变性被联系。甲状旁腺的荷尔蒙(PTH ) 在肾的失败涉及扰乱的钙 / 磷酸盐新陈代谢和 ostitis fibrosa 的开始。PTH 激活表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 在肾的管状的房间是在场的。这研究的目的是识别机制信号怎么是 transduced 导致细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵)激活，导致 CTGF.Methods 的 upregulation 在近似管状的房间( HK-2 )当面与 PTH 对待的人的肾或 MAPK 禁止者 PD98059 的缺席的 CTGF mRNA 和蛋白质的层次被量的即时聚合酶链反应( RT-PCR )和 immunoblotting 试金分析。在 HK-2 房间的 CTGF 倡导者的激活被双酶的试金决定。蛋白质 kinase A ( PKA )使活跃之物 8-Br-cAMP 和蛋白质 kinase C ( PKC )的效果 MAPK phosphorylation 上的使活跃之物 phorbol 12十四酸盐13醋酸盐( PMA )，并且 MAPK phosphorylation 和 CTGF 表示上的 PKA 禁止者 H89 和 PKC 禁止者 calphostin C 的效果被禁止的 immunoblotting assay.Results PD98059 检测 PTH 刺激了 CTGF 的表示，它强烈建议表明小径的 MAPK 在肾的 tu 在 导致PTH 的 CTGF upregulation 起一个重要作用象 PKC 使活跃之物一样的 PKA 使活跃之物导致了 MAPK phosphorylation，并且 PKA 和 PKC 禁止者反对了导致 PTH 的 MAPK phosphorylation 和 CTGF expression.Conclusion CTGF 表示是由通过一条 PKC/PKA-ERK-dependent 小径的 PTH 的 upregulated。" @default.
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- W3148334212 date "2010-01-01" @default.
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- W3148334212 title "Parathyroid hormone-mitogen-activated protein kinase axis exerts fibrogenic effect of connective tissue growth factor on human renal proximal tubular cells" @default.
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