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• W3148341722 abstract "Although bone substitutes associated with platelet concentrates are widely used to vertically recon- struct alveolar ridges, their respective and specific contri- bution remain controversial. The aim of this study was to evaluate the benefit of using either biphasic calcium phosphate (BCP) or demineralised bovine bone mineral (DBBM) alone or with autologous platelet lysate (APL) in vertical bone regeneration. The study involved fourteen New Zealand rabbits. Autologous APL was prepared by freeze-thawing from a platelet suspension (10 9 platelets/ ml). Four CP titanium (cpTi) cylinders were fixed to each calvarium; one cylinder was empty, one was filled with APL alone and the others were filled either with BCP or BCP ? APL or DBBM or DBBM ? APL. New bone formation and biomaterial resorption were evaluated using non-demineralised histology and histomorphometry. After 6 weeks, new bone formation was observed in all cylin- ders. The newly formed bone in the cylinders filled with APL alone, DBBM and BCP was significantly increased by (0.6-, 2.5- and 3.3-fold, respectively) (P 0.0001) com- pared to results obtained with the empty cylinders. Vertical bone height in the cylinders filled with BCP was greater to that observed with DBBM. The residual material in the cylinders filled with BCP was significantly (P 0.0001) lower (0.35-fold) than that with DBBM. Both newly formed bone and residual material in the cylinders filled with BCP ? APL or DBBM ? APL were similar to those filled with either BCP or DBBM, respectively. This study provided evidence that APL alone, as well as DBBM and BCP, have a beneficial effect on vertical bone formation and remodelling. APL associated with either DBBM or BCP did not provide additional benefits." @default.
• W3148341722 created "2021-04-13" @default.
• W3148341722 creator A5043439756 @default.
• W3148341722 date "2015-01-01" @default.
• W3148341722 modified "2023-09-27" @default.
• W3148341722 title "Vertical bone regeneration with deproteinised bovine bone mineral or biphasic calcium phosphate in the rabbit calvarium: effect of autologous platelet lysate" @default.
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