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- W3148359310 abstract "Summary. A double-blind randomized trial was conducted toresearch a hypercoagulable state rebound after abruptversus gradual withdrawal of acenocoumarol. 20 patientswere included: 10 in the abrupt withdrawal group (AW) and10 in the gradual withdrawal group (GW). Between days 1and 15, F1 2 was higher in group AW ( P < 0 : 002). A sig-nificant increase of D-dimer with time was found ( P < 0 : 001)withoutdifferencebetween the twogroups. tPA andPAI-1 levelsremained stable throughout without difference between thetwo groups. No rebound phenomenon was observed. Fourthrombotic recurrences were observed: group AW: 1, groupGW:3( P 0 : 29). There is neither clinical nor biologicalsupport for a gradual anticoagulation withdrawal. Keywords: venous thrombosis, oral anticoagulant, hyper-coagulable state, withdrawal.Thrombosis recurrence or ‘excessive’ increase in bloodclotting factors after abrupt oral anticoagulant withdrawal(Poller & Thomson, 1964; Dinon & Van der Veer, 1969;Harenberg" @default.
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- W3148359310 date "1997-01-01" @default.
- W3148359310 modified "2023-09-26" @default.
- W3148359310 title "Evolution of blood coagulation and fibrinolysis parameters after abrupt versus gradual withdrawal of acenocoumarol in patients with venous thromboembolism: a double-blind randomized study" @default.
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