Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148360867> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3148360867 abstract "Objective In order to investigate that ascorbic acid deficiency is responcible for lathyrus toxicity, the effect of dietary feeding of lathyrus pulse in normal and scorbutic guinea pigs for 3 months, on intestinal biochemical parameters was undertaken. Methods The intestinal brush border membrane (BBM) marker and xenobiotic metabolising enzymes (XME) were assayed. Results Exposure to 80% lathyrus alone and in scorbutic conditions showed significant inhibition of alkaline phosphatase (28%-30%), sucrase (19%) and γ-glutamyl transpeptidase (GGT) (15%-27%) enzymes, while Ca2+-Mg2+-ATPase was significantly inhibited (38%) in scorbutic plus lathyrus treated group. The phase I XME (AHH) remained unchanged while the phase II enzyme glutathione-S-tranferase (GST) was significantly decreased (20%-22%) in lathyrus and scorbutic plus lathyrus treated groups. Quinone reductase (QR) activity was found to be significantly decreased in lathyrus exposed group (20%). The intestinal biomarker contents including hexose (25%-34%) and phospholipids (20%-40%) were significantly reduced in lathyrus and scorbutic plus lathyrus exposed animals, while sialic acid showed a significant decrease (28%) in scorbutic plus lathyrus treated group. However, cholesterol levels were signifcantly enhanced (15%-28%) in lathyrus and scorbutic plus lathyrus treated animals. Conclusion The results indicate that oral feeding of lathyrus pulse to guinea pigs can alter BBM parameters as well as XME, which may result in the intestinal toxicity. Further, ascorbic acid deficiency could be one of the pre-disposing factors of lathyrus toxicity." @default.
- W3148360867 created "2021-04-13" @default.
- W3148360867 creator A5008396778 @default.
- W3148360867 creator A5085228917 @default.
- W3148360867 creator A5086581936 @default.
- W3148360867 date "2002-01-01" @default.
- W3148360867 modified "2023-09-23" @default.
- W3148360867 title "Effect of Dietary Administration of Lathyrus sativus Pulse on Intestinal Biochemical Parameters in Normal and Scorbutic Guinea Pigs" @default.
- W3148360867 hasPublicationYear "2002" @default.
- W3148360867 type Work @default.
- W3148360867 sameAs 3148360867 @default.
- W3148360867 citedByCount "0" @default.
- W3148360867 crossrefType "journal-article" @default.
- W3148360867 hasAuthorship W3148360867A5008396778 @default.
- W3148360867 hasAuthorship W3148360867A5085228917 @default.
- W3148360867 hasAuthorship W3148360867A5086581936 @default.
- W3148360867 hasConcept C126322002 @default.
- W3148360867 hasConcept C134018914 @default.
- W3148360867 hasConcept C185592680 @default.
- W3148360867 hasConcept C2776915367 @default.
- W3148360867 hasConcept C29730261 @default.
- W3148360867 hasConcept C2986274086 @default.
- W3148360867 hasConcept C31903555 @default.
- W3148360867 hasConcept C55493867 @default.
- W3148360867 hasConcept C59822182 @default.
- W3148360867 hasConcept C71924100 @default.
- W3148360867 hasConcept C86803240 @default.
- W3148360867 hasConceptScore W3148360867C126322002 @default.
- W3148360867 hasConceptScore W3148360867C134018914 @default.
- W3148360867 hasConceptScore W3148360867C185592680 @default.
- W3148360867 hasConceptScore W3148360867C2776915367 @default.
- W3148360867 hasConceptScore W3148360867C29730261 @default.
- W3148360867 hasConceptScore W3148360867C2986274086 @default.
- W3148360867 hasConceptScore W3148360867C31903555 @default.
- W3148360867 hasConceptScore W3148360867C55493867 @default.
- W3148360867 hasConceptScore W3148360867C59822182 @default.
- W3148360867 hasConceptScore W3148360867C71924100 @default.
- W3148360867 hasConceptScore W3148360867C86803240 @default.
- W3148360867 hasOpenAccess W3148360867 @default.
- W3148360867 hasRelatedWork W1577232341 @default.
- W3148360867 hasRelatedWork W1895806009 @default.
- W3148360867 hasRelatedWork W1948002250 @default.
- W3148360867 hasRelatedWork W1984388636 @default.
- W3148360867 hasRelatedWork W1987099280 @default.
- W3148360867 hasRelatedWork W200966790 @default.
- W3148360867 hasRelatedWork W2020181224 @default.
- W3148360867 hasRelatedWork W2040212318 @default.
- W3148360867 hasRelatedWork W2059391529 @default.
- W3148360867 hasRelatedWork W2069739512 @default.
- W3148360867 hasRelatedWork W2082070286 @default.
- W3148360867 hasRelatedWork W2091334047 @default.
- W3148360867 hasRelatedWork W2137395238 @default.
- W3148360867 hasRelatedWork W2156995344 @default.
- W3148360867 hasRelatedWork W2172083633 @default.
- W3148360867 hasRelatedWork W2409750496 @default.
- W3148360867 hasRelatedWork W2411980029 @default.
- W3148360867 hasRelatedWork W2417916314 @default.
- W3148360867 hasRelatedWork W2418027471 @default.
- W3148360867 hasRelatedWork W269143431 @default.
- W3148360867 isParatext "false" @default.
- W3148360867 isRetracted "false" @default.
- W3148360867 magId "3148360867" @default.
- W3148360867 workType "article" @default.