Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148362425> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3148362425 abstract "The aim of this study was to analyze the potential protective effect of Carvedilol against liver ischemia-reperfusion (I/R) injury in rats.A total of 40 Wistar albino rats were randomly divided into four groups (n=10 each). Group I (Sham/Control group) underwent only laparotomy, Group II (Carvedilol group) was administered carvedilol and then underwent laparotomy, Group III (I/R group) underwent laparotomy and hepatic ischemia/reperfusion, and Group IV (I/R + Carvedilol group) was administered carvedilol and then underwent laparotomy and hepatic ischemia/reperfusion. Blood samples were collected for malondialdehyde, glutathione (GSH), and myeloperoxidase (MPO) analysis. Liver sections were obtained for histopathological analysis and stained with hematoxy-lin-eosin. Tumor necrosis factor-α (TNF-α) and Caspase-3 primary antibodies were used for the immunohistochemical analysis.Serum GSH levels increased in the I/R + Carvedilol group. MPO activity was increased significantly in the IR group. In I/R + Carvedilol group, serum MPO levels were similar to the control group. Histopathological findings showed reduced dilatation and congestion in vena centralis, regenerative changes in hepatocyte cells with the protected nucleus structure in the I/R + Carvedilol group. Hepatocyte nuclei with increased pycnosis and apoptosis and the dilated vena centralis were observed in I/R group. In the control group, TNF-α showed a positive reaction in macrophage cells around vena centralis. An increase in TNF-α expression was observed in hepatocyte cells of I/R group. Positive expression of caspase-3 in hepatocyte cells and a small number of endothelial and Kupffer cells were seen in I/R group. However, negative caspase-3 expression was seen in hepatocyte, endothelial, and Kupffer cells in I/R + Carvedilol group.Carvedilol may prevent initiation of oxidative stress process, inflammation induction and apoptotic progression." @default.
- W3148362425 created "2021-04-13" @default.
- W3148362425 creator A5070837783 @default.
- W3148362425 date "2021-01-01" @default.
- W3148362425 modified "2023-09-23" @default.
- W3148362425 title "Effects of Carvedilol on Liver Ischemia-Reperfusion Injury in Rats" @default.
- W3148362425 cites W1852807501 @default.
- W3148362425 cites W1970681737 @default.
- W3148362425 cites W1976000427 @default.
- W3148362425 cites W2004906215 @default.
- W3148362425 cites W2018597616 @default.
- W3148362425 cites W2021161307 @default.
- W3148362425 cites W2033602484 @default.
- W3148362425 cites W2034982904 @default.
- W3148362425 cites W2049110705 @default.
- W3148362425 cites W2052289997 @default.
- W3148362425 cites W2069195017 @default.
- W3148362425 cites W2073251997 @default.
- W3148362425 cites W2075046188 @default.
- W3148362425 cites W2087877138 @default.
- W3148362425 cites W2110565948 @default.
- W3148362425 cites W2118296121 @default.
- W3148362425 cites W2121841947 @default.
- W3148362425 cites W2136227880 @default.
- W3148362425 cites W2158501840 @default.
- W3148362425 cites W2170597525 @default.
- W3148362425 cites W2347027448 @default.
- W3148362425 cites W2471199165 @default.
- W3148362425 cites W2739873258 @default.
- W3148362425 cites W2754635324 @default.
- W3148362425 cites W2890149744 @default.
- W3148362425 cites W2950834644 @default.
- W3148362425 doi "https://doi.org/10.14744/tjtes.2021.57824" @default.
- W3148362425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35775675" @default.
- W3148362425 hasPublicationYear "2021" @default.
- W3148362425 type Work @default.
- W3148362425 sameAs 3148362425 @default.
- W3148362425 citedByCount "0" @default.
- W3148362425 crossrefType "journal-article" @default.
- W3148362425 hasAuthorship W3148362425A5070837783 @default.
- W3148362425 hasConcept C126322002 @default.
- W3148362425 hasConcept C134018914 @default.
- W3148362425 hasConcept C141071460 @default.
- W3148362425 hasConcept C142724271 @default.
- W3148362425 hasConcept C185592680 @default.
- W3148362425 hasConcept C202751555 @default.
- W3148362425 hasConcept C203565725 @default.
- W3148362425 hasConcept C2776151105 @default.
- W3148362425 hasConcept C2776200302 @default.
- W3148362425 hasConcept C2776637226 @default.
- W3148362425 hasConcept C2776914184 @default.
- W3148362425 hasConcept C2778198053 @default.
- W3148362425 hasConcept C2778401633 @default.
- W3148362425 hasConcept C2780114680 @default.
- W3148362425 hasConcept C2780591200 @default.
- W3148362425 hasConcept C2780778865 @default.
- W3148362425 hasConcept C541997718 @default.
- W3148362425 hasConcept C55493867 @default.
- W3148362425 hasConcept C71924100 @default.
- W3148362425 hasConceptScore W3148362425C126322002 @default.
- W3148362425 hasConceptScore W3148362425C134018914 @default.
- W3148362425 hasConceptScore W3148362425C141071460 @default.
- W3148362425 hasConceptScore W3148362425C142724271 @default.
- W3148362425 hasConceptScore W3148362425C185592680 @default.
- W3148362425 hasConceptScore W3148362425C202751555 @default.
- W3148362425 hasConceptScore W3148362425C203565725 @default.
- W3148362425 hasConceptScore W3148362425C2776151105 @default.
- W3148362425 hasConceptScore W3148362425C2776200302 @default.
- W3148362425 hasConceptScore W3148362425C2776637226 @default.
- W3148362425 hasConceptScore W3148362425C2776914184 @default.
- W3148362425 hasConceptScore W3148362425C2778198053 @default.
- W3148362425 hasConceptScore W3148362425C2778401633 @default.
- W3148362425 hasConceptScore W3148362425C2780114680 @default.
- W3148362425 hasConceptScore W3148362425C2780591200 @default.
- W3148362425 hasConceptScore W3148362425C2780778865 @default.
- W3148362425 hasConceptScore W3148362425C541997718 @default.
- W3148362425 hasConceptScore W3148362425C55493867 @default.
- W3148362425 hasConceptScore W3148362425C71924100 @default.
- W3148362425 hasLocation W31483624251 @default.
- W3148362425 hasLocation W31483624252 @default.
- W3148362425 hasOpenAccess W3148362425 @default.
- W3148362425 hasPrimaryLocation W31483624251 @default.
- W3148362425 hasRelatedWork W1855195526 @default.
- W3148362425 hasRelatedWork W1921357624 @default.
- W3148362425 hasRelatedWork W1981080208 @default.
- W3148362425 hasRelatedWork W1985579713 @default.
- W3148362425 hasRelatedWork W2044988659 @default.
- W3148362425 hasRelatedWork W2094423915 @default.
- W3148362425 hasRelatedWork W2151391157 @default.
- W3148362425 hasRelatedWork W2372600214 @default.
- W3148362425 hasRelatedWork W2466450716 @default.
- W3148362425 hasRelatedWork W2337002345 @default.
- W3148362425 isParatext "false" @default.
- W3148362425 isRetracted "false" @default.
- W3148362425 magId "3148362425" @default.
- W3148362425 workType "article" @default.