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- W3148366886 abstract "Publisher Summary This chapter describes the available techniques for multiple and library synthesis of peptides. It focuses on synthetic techniques that can be immediately applied in most laboratories—that is, techniques that do not require major capital investment and instrumentation. Appropriate mind-set is needed for the use of library techniques. The very origin of all multiple and combinatorial syntheses resides with the frustration of Merrifield with the tediousness of peptide synthesis in solution. The concept of synthesizing peptides on the solid phase seems obvious—a large excess of reagents is used to drive reactions to near completion, any soluble material is readily removed by filtration, and, owing to the fact that individual steps include either addition of liquid to the solid phase or separation of solid and liquid phases, the whole process can easily be automated. The advantages of the solid-phase concept are more useful for multiple syntheses and the generation of combinatorial libraries." @default.
- W3148366886 created "2021-04-13" @default.
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- W3148366886 date "2010-06-23" @default.
- W3148366886 modified "2023-10-10" @default.
- W3148366886 title "ChemInform Abstract: Synthetic Peptide Libraries" @default.
- W3148366886 cites W2950392431 @default.
- W3148366886 doi "https://doi.org/10.1002/chin.199810311" @default.
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