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- W3148376977 abstract "Summary Brrckgmui7d: Epidemiologic evidence suggests that an elevated heart rate (HR) is an adverse and independent prognostic factor in arterial hypertension and other cardiovascular diseases. Although diltiazem is characterized as an HR-lowering calcium antagonist, no studies have quantified the magnitude of HR changes in patients with angina or hypertension. Hypothesis: The study was undertaken to explore the magnitude of proportional HR reduction at varying levels of resting HR with the sustained-release formulation of diltiazem (SR diltiazem) at the usual clinical doses of 200 or 300 mg once daily. Morlzods: This meta-analysis was conducted on six comparative double-blind studies including 77 1 patients with angina or hypertension in which SR diltiazem 200-300 mg once daily was compared either with placebo or with other agents known not to influence HR (angiotensin-converting enzyme inhibitors, diuretics). Sustained-release diltiazem decreases elevated baseline HR, with an increasing effect at higher initial rates. Results: Multiple comparisons by baseline HR category showed a significant difference between both groups for baseline HR of 74-84 beats/min and 2 85 beatdmin (p = 0.001 ). Sustained-release diltiazem had no significant HR-decreasing" @default.
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- W3148376977 date "2001-01-01" @default.
- W3148376977 modified "2023-09-27" @default.
- W3148376977 title "Heart Rate-Lowering and -Regulating Effects of Once-Daily Sustained- Release Diltiazem" @default.
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