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- W3148393296 abstract "Objective To evaluate the relation between complement 4 genetic pol ymorphism and complement activation during extracorporeal circulation in open he art surgery among children. Methods One hundred and fifty-six children to und e rgo open heart surgery with cardiopulmonary bypass in Wuhan and surrounding area s were investigated. Blood samples were obtained before the operation to analyze the C4 phenotypes by crossed immunoelectrophoresis. Before the initiation of CP B, at the end of CPB, and 10 minutes after protamine infusion, arterial blood sa mples were drawn to test the C4a and C3a with radioimmunoassay and lung complian ce was recorded. Results The frequencies of C4 genetic phenotypes AABB, AOBB, OOBB, AABO, and AAOO were 51.28%, 17.95%, 4.49%, and 19.80% respectively among t he investigated children. At the end of CPB, The C4a levels remained almost the same, and C3a levels increased significantly. Ten minutes after the protamine in fusion, significant increase was seen in the levels of both C4a and C3a, especia lly in the OOBB phenotype group followed by AOBB phenotype group. The lung compl iance began to decrease by the end of CPB, most significantly in the OOBB phenot ype group, followed by the AOBB group, along with the increase of C4a level. Conclusion The complement system is activated by the alternative pathway during C PB and by the classic way during the formation of protamine-heparin complexes. T he complement system is activated and the lung function is damaged the most seri ously during CPB among the persons with OOBB phenotype. The frequency of OOBB ph enotype is higher among Chinese than among Caucasians." @default.
- W3148393296 created "2021-04-13" @default.
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- W3148393296 date "2001-01-01" @default.
- W3148393296 modified "2023-09-23" @default.
- W3148393296 title "Effect of complement 4 genetic polymorphism on complement activation during cardiopulmonary bypass in open heart surgery among child ren" @default.
- W3148393296 hasPublicationYear "2001" @default.
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