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- W3148394949 abstract "Objective To investigate the molecular mechanisms of body development and growth regulatedby nutritional status.Methods Effects of fasting on the expression of insulin-like growth factor-Ⅰ (IGF-Ⅰ)andIGF binding protein-1 (IGFBP-1)genes were analyzed by northern blotting technique in rats.Results Fasting for48 hours, body weight of the rats decreased by 11.8%,level of blood glucose by 50.8% and content of IGF-ⅠmRNA in the liver by 32.7%(P0.05).On the contrary, content of IGFBP-1 mRNA in the liver of fasted ratsincreased gradually, with a 2.5 time increase after 24 h fasting (P0.05). There was no sigificant change inthe level of liver albumin mRNA after fasting. Conclusion Fasting could inhibit the expression of IGF-Ⅰ geneand enhance the expression of IGFBP-1 gene." @default.
- W3148394949 created "2021-04-13" @default.
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- W3148394949 date "1999-01-01" @default.
- W3148394949 modified "2023-09-25" @default.
- W3148394949 title "Effects of Fasting on Exression of Insulin-like Growth Factor-I and IGF Binding Protein-1 Genes in the Liver of RatsE" @default.
- W3148394949 hasPublicationYear "1999" @default.
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