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- W3148398055 abstract "Many advances have been recently made in understanding the genetic control of fertility in model systems. This review concentrates on genetic causes of male factor infertility in mammalian models. More than 150 genes proved to be important for the male fer- tility in mammals and the list is continuously growing. Most of those genes were discovered using gene target- ing in the mouse. Here, several interesting male infer- tility mutations are described with regard to the pathogenesis of reproduction failure. A detailed table comprising most of the genes causing male infertility is presented as supplementary Table 1, at http://www.img.cas.cz/fb/v49no4_table1.html, including the corresponding references. Infertility is a major health problem: approximately 15% of couples worldwide suffer from infertility, and the male factor accounts for about half of these cases (for review see Feng, 2003). A large proportion of these men fail to conceive because of lack of sperm (azoospermia) or too little sperm (oligospermia). Other phenotypic manifestations include abnormal sperm morphology (teratospermia) and insufficient sperm motility (asthenospermia). Although the cause of these defects of spermatogenesis is often unclear in humans, recent efforts point out the importance of the environ- mental as well as genetic factors in the development of male infertility. The explosive growth of assisted repro- duction (in vitro fertilization techniques, IVF) should focus our attention to the genetic causes as, of course, unrestricted use of these techniques could lead to trans- mission of the responsible genetic defects to successive generations and their unwanted accumulation in the population. Our knowledge of underlying genetic defects could, however, promote appropriate genetic counselling (prevention) or even gene therapy. Because of the small family size and the lack of transmission from affected males (with the exception of IVF), humans are not ideal for the experimental dissection of infertility igenesi. Animal models are thus a very" @default.
- W3148398055 created "2021-04-13" @default.
- W3148398055 creator A5048761482 @default.
- W3148398055 date "2003-01-01" @default.
- W3148398055 modified "2023-09-24" @default.
- W3148398055 title "Selected Genetic Aspects of Male Infertility ñ What Animal Models Tell Us" @default.
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