FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148404689> ?p ?o ?g. }

• W3148404689 endingPage "114096" @default.
• W3148404689 startingPage "114096" @default.
• W3148404689 abstract "Abstract Ethnopharmacological relevance The increasing use of “kidney”-nourishing Traditional Chinese Medicine (TCM) like Er-xian decoction (EXD) for management of menopausal symptoms and osteoporosis has aroused concerns about their safety, and whether they interact with prescription drugs as both of them act via estrogen receptors (ERs) and regulate serum estradiol. Aim of the study The present study aimed to evaluate whether EXD selectively exerted estrogenic activities and interacted with Selective Estrogen Receptor Modulators (SERMs). Materials and methods In vivo, mature ovariectomized (OVX) rats were administrated with EXD or combined treatment of EXD and SERMs for 12 weeks. The tissue-selective effect of EXD and its interaction of SERMs were studied in four estrogen sensitive tissues, bone, brain, breast and uterus. In vitro, the interaction of extracts of EXD-treated serum and SERMs in four ER-positive cell lines. Results In OVX rats, EXD selectively alleviated estrogen deficiency-induced changes in the bone and brain without inducing any estrogenic effects in the breast or uterus. Two-way ANOVA indicated the presence of interactions between EXD and SERMs in OVX rats but EXD did not significantly alter the tissue responses to SERMs in the bone, breast or brain. Indeed, the combined use of EXD and SERMs appeared to suppress the estrogenic effect of raloxifene and tamoxifen in the uterus. Extract of EXD-treated serum directly stimulated cell proliferation or differentiation in human osteosarcoma MG-63, neuroblastoma SHSY5Y, breast cancer MCF-7, and endometrial Ishikawa cells. Two-way ANOVA revealed that EXD-treated serum interacted with SERMs at various concentrations and altered the effects of tamoxifen in MG-63 and MCF-7 cells. Conclusions EXD exerted estrogenic effects in a tissue-selective manner and interacted with SERMs. Combined treatment of EXD and SERMs did not hamper the beneficial effects of SERMs on the bone or brain but appeared to moderate the estrogenic effect of SERMs in the uterus." @default.
• W3148404689 created "2021-04-13" @default.
• W3148404689 creator A5012877626 @default.
• W3148404689 creator A5022200033 @default.
• W3148404689 creator A5028235293 @default.
• W3148404689 creator A5037692904 @default.
• W3148404689 creator A5046014289 @default.
• W3148404689 creator A5065914188 @default.
• W3148404689 creator A5085645609 @default.
• W3148404689 creator A5090225916 @default.
• W3148404689 date "2021-07-01" @default.
• W3148404689 modified "2023-09-27" @default.
• W3148404689 title "Water extract of Er-xian decoction selectively exerts estrogenic activities and interacts with SERMs in estrogen-sensitive tissues" @default.
• W3148404689 cites W1593442063 @default.
• W3148404689 cites W1677564607 @default.
• W3148404689 cites W1979867396 @default.
• W3148404689 cites W1984873736 @default.
• W3148404689 cites W2001889167 @default.
• W3148404689 cites W2010929099 @default.
• W3148404689 cites W2014068091 @default.
• W3148404689 cites W2037551404 @default.
• W3148404689 cites W2040887624 @default.
• W3148404689 cites W2046327259 @default.
• W3148404689 cites W2055657712 @default.
• W3148404689 cites W2063793220 @default.
• W3148404689 cites W2064543792 @default.
• W3148404689 cites W2075506379 @default.
• W3148404689 cites W2097834597 @default.
• W3148404689 cites W2098505104 @default.
• W3148404689 cites W2119146135 @default.
• W3148404689 cites W2139159246 @default.
• W3148404689 cites W2146029421 @default.
• W3148404689 cites W2150841738 @default.
• W3148404689 cites W2159873510 @default.
• W3148404689 cites W2326964709 @default.
• W3148404689 cites W2597862587 @default.
• W3148404689 cites W2767627749 @default.
• W3148404689 cites W2802956916 @default.
• W3148404689 cites W2802959681 @default.
• W3148404689 cites W2803023374 @default.
• W3148404689 cites W2839455098 @default.
• W3148404689 cites W2885499559 @default.
• W3148404689 cites W2921351522 @default.
• W3148404689 cites W2934839137 @default.
• W3148404689 cites W3032026461 @default.
• W3148404689 cites W3144959505 @default.
• W3148404689 doi "https://doi.org/10.1016/j.jep.2021.114096" @default.
• W3148404689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33823166" @default.
• W3148404689 hasPublicationYear "2021" @default.
• W3148404689 type Work @default.
• W3148404689 sameAs 3148404689 @default.
• W3148404689 citedByCount "3" @default.
• W3148404689 countsByYear W31484046892022 @default.
• W3148404689 crossrefType "journal-article" @default.
• W3148404689 hasAuthorship W3148404689A5012877626 @default.
• W3148404689 hasAuthorship W3148404689A5022200033 @default.
• W3148404689 hasAuthorship W3148404689A5028235293 @default.
• W3148404689 hasAuthorship W3148404689A5037692904 @default.
• W3148404689 hasAuthorship W3148404689A5046014289 @default.
• W3148404689 hasAuthorship W3148404689A5065914188 @default.
• W3148404689 hasAuthorship W3148404689A5085645609 @default.
• W3148404689 hasAuthorship W3148404689A5090225916 @default.
• W3148404689 hasConcept C116073593 @default.
• W3148404689 hasConcept C121608353 @default.
• W3148404689 hasConcept C126322002 @default.
• W3148404689 hasConcept C134018914 @default.
• W3148404689 hasConcept C160492267 @default.
• W3148404689 hasConcept C185592680 @default.
• W3148404689 hasConcept C190409667 @default.
• W3148404689 hasConcept C202751555 @default.
• W3148404689 hasConcept C2777164284 @default.
• W3148404689 hasConcept C2777176818 @default.
• W3148404689 hasConcept C2777944059 @default.
• W3148404689 hasConcept C530470458 @default.
• W3148404689 hasConcept C55493867 @default.
• W3148404689 hasConcept C556039675 @default.
• W3148404689 hasConcept C71924100 @default.
• W3148404689 hasConcept C98274493 @default.
• W3148404689 hasConceptScore W3148404689C116073593 @default.
• W3148404689 hasConceptScore W3148404689C121608353 @default.
• W3148404689 hasConceptScore W3148404689C126322002 @default.
• W3148404689 hasConceptScore W3148404689C134018914 @default.
• W3148404689 hasConceptScore W3148404689C160492267 @default.
• W3148404689 hasConceptScore W3148404689C185592680 @default.
• W3148404689 hasConceptScore W3148404689C190409667 @default.
• W3148404689 hasConceptScore W3148404689C202751555 @default.
• W3148404689 hasConceptScore W3148404689C2777164284 @default.
• W3148404689 hasConceptScore W3148404689C2777176818 @default.
• W3148404689 hasConceptScore W3148404689C2777944059 @default.
• W3148404689 hasConceptScore W3148404689C530470458 @default.
• W3148404689 hasConceptScore W3148404689C55493867 @default.
• W3148404689 hasConceptScore W3148404689C556039675 @default.
• W3148404689 hasConceptScore W3148404689C71924100 @default.
• W3148404689 hasConceptScore W3148404689C98274493 @default.
• W3148404689 hasLocation W31484046891 @default.
• W3148404689 hasOpenAccess W3148404689 @default.
• W3148404689 hasPrimaryLocation W31484046891 @default.
• W3148404689 hasRelatedWork W1514515741 @default.

• next