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- W3148406903 abstract "Amphiphilic 块共聚物(ABC ) 集合进球形的 nanoscopic 超分子的核心 / 壳 nanostructure 称为广泛地为糟糕水溶性的 anticancer 代理人作为血管注射剂 nanocarrier 被研究了的聚合 micelle。这篇评论文章的目的是向临床的试用在药交货的领域里更新进步，加亮在为由提高的渗透和保留(EPR ) 效果指向的药增溶，减少的离开目标毒性和肿瘤使用的聚合微粒的进展。聚合微粒在血和药版本率在稳定性变化，并且因此在药交货起不同却关键的作用。为静脉内(IV ) 注入，聚合微粒在血拆卸并且很快释放象 paclitaxel 那样的糟糕水溶性的 anticancer 代理人相对存在增溶的代理人被用于药增溶，安全和毒性减小的不同可能性，例如， Cremophor EL。稳定的聚合微粒在血和还原剂分发是长传播的到非目标织物，降低离开目标毒性。进一步，他们在鼠科的肿瘤模型参予 EPR 效果。在是的概括、聚合微粒行为为糟糕水溶性的 anticancer 代理人的血管注射剂 nanocarriers，完成减少的毒性并且由 EPR 效果指向肿瘤。" @default.
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- W3148406903 date "2016-01-01" @default.
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- W3148406903 title "Polymeric micelle nanocarriers in cancer research" @default.
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