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- W3148423484 abstract "Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, which is essential for DNA synthesis and methylation. Genetic variations in the MTHFR gene seem to contribute to a decreased activity of MTHFR, ultimately confer increased susceptibility to cancer. As the most extensively studied polymorphism, MTHFR C677T polymorphism was shown to contribute to cancer susceptibility but the results were inconsistent. The authors performed a meta-analysis including 134 studies (46,207 cases and 69,160 controls) to address the issue. Odds ratios (ORs) with corresponding 95 % confidence intervals (CIs) were used to assess the association. Overall, a significant elevated risk of cancer was associated with the MTHFR C677T polymorphism in T-allele versus C-allele comparison (OR = 1.06, 95 % CI 1.02-1.11, Pheterogeneity 0.001), homozygote model (OR = 1.08, 95 % CI 1.01-1.17, Pheterogeneity 0.001) and dominant model (OR = 1.05, 95 % CI 1.00-1.10, Pheterogeneity 0.001). In the stratified analyses, signifi- cantly increased cancer risks were indicated among Asians in all genetic models except for heterozygote model. Further analysis revealed that C677T was significantly associated with an increased risk of esophageal and stom- ach cancer. This meta-analysis supports an association between the MTHFR C677T polymorphism and increased risk of esophageal and stomach cancer, especially among Asians. Additionally, more high-quality studies and that the covariates responsible for heterogeneity should be controlled to obtain a more conclusive response about the function of MTHFR C677T in cancer." @default.
- W3148423484 created "2021-04-13" @default.
- W3148423484 creator A5048921315 @default.
- W3148423484 creator A5062784242 @default.
- W3148423484 date "2014-01-01" @default.
- W3148423484 modified "2023-09-27" @default.
- W3148423484 title "The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control" @default.
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