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- W31484260 abstract "The physiological reaction of tumor tissue and the progression of normal vascular and cellular repair processes in the body after thermal ablation suggest specific ways that adjuvant therapies may improve tumor control. This is a topic of growing importance as thermal ablation techniques are being used more than ever yet continue to have significant and unpredictable recurrence rates in clinical settings. We hypothesized that incomplete ablation of tumor tissue near the margin and around major blood vessels allows re-oxygenation and repopulation of the tumor. Microvessel functionality after partial thermal ablation of experimental murine tumors has been investigated after both high and low temperature thermal ablations. Interestingly, the oxygenation in the tumor margin increased from 1.2 ± 0.98 mmHg to 10.4 ± 6.3 mmHg during and for the first 20–30 min after a typical hot or cold ablation session, suggesting that the vascular response is a common feature to all of ablative medicine. Vessels with active blood flow in the peripheral regions of the tumor were seen to persist at varying levels from 24–72 h post-ablation. The level of hypoxia detected by pimonidazole binding was inversely related to the number of functional vessels detected. Our results suggest that simultaneous or tightly sequenced ablation and ionizing radiation therapy may have merit as an efficient means to completely sterilize tumor volume since radiation is most cytotoxic in areas of improved oxygenation and ablation most effectively debulks volumes with low or impaired perfusion. Furthermore, nanomedicine or other vascular-targeted drugs that can selectively impair the vasculature of the tumor may significantly increase the volume of complete ablation obtained and improve reproducibility of the ablation zone from tumor to tumor. A vascular sensitizing/damaging agent may also increase the overall effect of radiotherapy and thus improve tumor control. We have also documented a contribution of progenitor cells in repairing sublethally damaged tissue after ablation and promoting establishment of a vascular niche capable of regenerating the tumor mass which suggests agents that block the mobilization of bone marrow derived cells could also serve to improve the results of thermal ablative therapy for a variety of tumor types. These aspects of combined treatments will be discussed for both high temperature ablations and cryosurgery. Supported by NCI CA44114, Arkansas Breast Cancer Research Program and the Winthrop P. Rockefeller Cancer Institute at UAMS." @default.
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- W31484260 date "2014-08-01" @default.
- W31484260 modified "2023-09-27" @default.
- W31484260 title "A34 Session 10: Adjunctive Therapeutic Approaches" @default.
- W31484260 doi "https://doi.org/10.1016/j.cryobiol.2014.06.043" @default.
- W31484260 hasPublicationYear "2014" @default.
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