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- W3148477375 abstract "低剂量的全部的身体照耀(LTBI ) 主要为杀死的有免疫力的改进而非房间在 somecancers 的治疗被使用。然而，位于 LTBI 下面的 themechanism 仍然保持未知。在这研究，由分析淋巴细胞的 theimmune 模式，我们发现 CD4+CD25+Foxp3+regulatory T 房间的百分比和 absolutenumber 显著地在跟随 treatmentwith LTBI 的天真的老鼠被减少。相反， CD4+CD44+/CD8+CD44+effector-memory T 房间极大地被增加。重要地，天真的老鼠 treatedwith 在 LTBI 下面的树枝状的 cell-gp100 肿瘤疫苗导致了 enhancementof 抗原特定的增长和 cytotoxicity 以及干扰素 -- 对 F10 黑瘤肿瘤挑战的纬(IFN- 纬) 分泌物，与 treatmentwith 相比肿瘤疫苗或 LTBI 独自一个。因而，处理 resultedin 减少的肿瘤负担和延长老鼠幸存。我们 antitumor 免疫的数据 demonstratethat LTBI 鈥檚 改进主要是有选择地减少的 associatedwith T 规章的房间的比例和数字，在 antitumor 暗示 LTBI 和 tumorvaccine 的联合的潜在的应用程序治疗。" @default.
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- W3148477375 date "2010-01-01" @default.
- W3148477375 modified "2023-09-27" @default.
- W3148477375 title "Enhancement of antitumor immunity by low-dose total body irradiation is associated with selectively decreasing the proportion and number of T regulatory cells" @default.
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