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• W3148485074 abstract "Background Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphism, which may affect host immune response including cytokines production, is thought to be associated with hepatitis B virus (HBV) infection. This study investigated the associations between CTLA4 polymorphism and serum tumor necrosis factor (TNF)-a and interferon (IFN)-c levels in patients with chronic HBV infection. Methods CTLA4 promoter -318C/T and exon 1 ?49A/G polymorphisms and serum TNF-a and IFN-c levels were determined in 172 patients with chronic HBV infection and 145 healthy controls. Results The genotype of CTLA4 -318C/T polymorphism had no association to TNF-a and IFN-c levels. Serum levels of TNF-a and IFN-c in chronic HBV patients with ?49GG genotype were lower than those with ?49AG genotype (p = 0.030 and p = 0.042, respectively), and haplotypes -318C ? 49A and -318C ? 49G seemed to have no significant effects on TNF-a and IFN-c levels. Conclusions CTLA4 ?49GG genotype was associated to lower TNF-a and IFN-c levels in patients with chronic HBV infection but this association was diminished by haplotype formation with -318C/T alleles, indicating that the influence of CTLA4 -318C/T and ?49A/G polymorphisms on the susceptibility and disease progress of chronic HBV infection may not be effectuated by affecting TNF-a and IFN-c secretion." @default.
• W3148485074 created "2021-04-13" @default.
• W3148485074 creator A5064522694 @default.
• W3148485074 date "2011-01-01" @default.
• W3148485074 modified "2023-09-27" @default.
• W3148485074 title "Associations between cytotoxic T lymphocyte-associated antigen-4 polymorphisms and serum tumor necrosis factor-a and interferon-c levels in patients with chronic hepatitis B virus infection" @default.
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