Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148485711> ?p ?o ?g. }
- W3148485711 endingPage "e2371" @default.
- W3148485711 startingPage "e2363" @default.
- W3148485711 abstract "To investigate the prevalence, predictors, and prognostic effect of hematoma expansion (HE) in patients with intracerebral hemorrhage (ICH) with unclear symptom onset (USO).We performed a retrospective analysis of patients with primary spontaneous ICH admitted at 5 academic medical centers in the United States and Italy. HE (volume increase >6 mL or >33% from baseline to follow-up noncontrast CT [NCCT]) and mortality at 30 days were the outcomes of interest. Baseline NCCT was also analyzed for presence of hypodensities (any hypodense region within the hematoma margins). Predictors of HE and mortality were explored with multivariable logistic regression.We enrolled 2,165 participants, 1,022 in the development cohort and 1,143 in the replication cohort, of whom 352 (34.4%) and 407 (35.6%) had ICH with USO, respectively. When compared with participants having a clear symptom onset, patients with USO had a similar frequency of HE (25.0% vs 21.9%, p = 0.269 and 29.9% vs 31.5%, p = 0.423). Among patients with USO, HE was independently associated with mortality after adjustment for confounders (odds ratio [OR] 2.64, 95% confidence interval [CI] 1.43-4.89, p = 0.002). This finding was similar in the replication cohort (OR 3.46, 95% CI 1.86-6.44, p < 0.001). The presence of NCCT hypodensities in patients with USO was an independent predictor of HE in the development (OR 2.59, 95% CI 1.27-5.28, p = 0.009) and replication (OR 2.43, 95% CI 1.42-4.17, p = 0.001) population.HE is common in patients with USO and independently associated with worse outcome. These findings suggest that patients with USO may be enrolled in clinical trials of medical treatments targeting HE." @default.
- W3148485711 created "2021-04-13" @default.
- W3148485711 creator A5000274637 @default.
- W3148485711 creator A5000497722 @default.
- W3148485711 creator A5001829677 @default.
- W3148485711 creator A5005945990 @default.
- W3148485711 creator A5006664647 @default.
- W3148485711 creator A5014564210 @default.
- W3148485711 creator A5023490483 @default.
- W3148485711 creator A5024343949 @default.
- W3148485711 creator A5025315449 @default.
- W3148485711 creator A5029838262 @default.
- W3148485711 creator A5034002772 @default.
- W3148485711 creator A5034035251 @default.
- W3148485711 creator A5035635520 @default.
- W3148485711 creator A5038510989 @default.
- W3148485711 creator A5042119710 @default.
- W3148485711 creator A5045259974 @default.
- W3148485711 creator A5045439266 @default.
- W3148485711 creator A5047787732 @default.
- W3148485711 creator A5048150424 @default.
- W3148485711 creator A5053362661 @default.
- W3148485711 creator A5055949791 @default.
- W3148485711 creator A5056929092 @default.
- W3148485711 creator A5061174828 @default.
- W3148485711 creator A5062641264 @default.
- W3148485711 creator A5063509357 @default.
- W3148485711 creator A5064705910 @default.
- W3148485711 creator A5072737556 @default.
- W3148485711 creator A5086563558 @default.
- W3148485711 creator A5087139584 @default.
- W3148485711 creator A5087662189 @default.
- W3148485711 creator A5089967868 @default.
- W3148485711 creator A5090574793 @default.
- W3148485711 creator A5091627430 @default.
- W3148485711 date "2021-05-11" @default.
- W3148485711 modified "2023-10-13" @default.
- W3148485711 title "Hematoma Expansion in Intracerebral Hemorrhage With Unclear Onset" @default.
- W3148485711 cites W1947113872 @default.
- W3148485711 cites W1966921182 @default.
- W3148485711 cites W1968514614 @default.
- W3148485711 cites W1989670622 @default.
- W3148485711 cites W1991339447 @default.
- W3148485711 cites W2007301755 @default.
- W3148485711 cites W2009569999 @default.
- W3148485711 cites W2062443077 @default.
- W3148485711 cites W2075849746 @default.
- W3148485711 cites W2089463633 @default.
- W3148485711 cites W2091313310 @default.
- W3148485711 cites W2105908213 @default.
- W3148485711 cites W2108897505 @default.
- W3148485711 cites W2114214167 @default.
- W3148485711 cites W2138238488 @default.
- W3148485711 cites W2142408876 @default.
- W3148485711 cites W2147199549 @default.
- W3148485711 cites W2151432761 @default.
- W3148485711 cites W2156589326 @default.
- W3148485711 cites W2214011890 @default.
- W3148485711 cites W2282654601 @default.
- W3148485711 cites W2359269788 @default.
- W3148485711 cites W2409181187 @default.
- W3148485711 cites W2464497605 @default.
- W3148485711 cites W2548934243 @default.
- W3148485711 cites W2601236294 @default.
- W3148485711 cites W2626309417 @default.
- W3148485711 cites W2736030159 @default.
- W3148485711 cites W2761279809 @default.
- W3148485711 cites W2804714053 @default.
- W3148485711 cites W2887567733 @default.
- W3148485711 cites W2925108450 @default.
- W3148485711 cites W2963377809 @default.
- W3148485711 cites W2964749322 @default.
- W3148485711 cites W2966481455 @default.
- W3148485711 cites W2969289969 @default.
- W3148485711 cites W2969397400 @default.
- W3148485711 cites W3006110199 @default.
- W3148485711 cites W3029589626 @default.
- W3148485711 cites W3080226789 @default.
- W3148485711 cites W3100382058 @default.
- W3148485711 cites W3171831654 @default.
- W3148485711 cites W4248217291 @default.
- W3148485711 doi "https://doi.org/10.1212/wnl.0000000000011895" @default.
- W3148485711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8166446" @default.
- W3148485711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33795389" @default.
- W3148485711 hasPublicationYear "2021" @default.
- W3148485711 type Work @default.
- W3148485711 sameAs 3148485711 @default.
- W3148485711 citedByCount "15" @default.
- W3148485711 countsByYear W31484857112021 @default.
- W3148485711 countsByYear W31484857112022 @default.
- W3148485711 countsByYear W31484857112023 @default.
- W3148485711 crossrefType "journal-article" @default.
- W3148485711 hasAuthorship W3148485711A5000274637 @default.
- W3148485711 hasAuthorship W3148485711A5000497722 @default.
- W3148485711 hasAuthorship W3148485711A5001829677 @default.
- W3148485711 hasAuthorship W3148485711A5005945990 @default.
- W3148485711 hasAuthorship W3148485711A5006664647 @default.
- W3148485711 hasAuthorship W3148485711A5014564210 @default.