Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148503912> ?p ?o ?g. }
- W3148503912 endingPage "141" @default.
- W3148503912 startingPage "129" @default.
- W3148503912 abstract "The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the activation of the antioxidant cytoprotective pathway and other important physiological processes to maintain cellular homeostasis. The dysregulation of NRF2 activity plays a role in various diseases, such as cardiovascular diseases, neurodegenerative diseases, and cancer. Thus, NRF2 activity is tightly regulated through multiple mechanisms, among which phosphorylation by kinases is critical in the posttranslational regulation of NRF2. For instance, PKC, casein kinase 2, and AMP-activated kinase positively, while GSK-3 negatively regulates NRF2 activity through phosphorylation of different sites. Here, we provide an overview of the phosphorylation regulation pattern of NRF2 and discuss the therapeutic potential of interventions targeting NRF2 phosphorylation. • Protein kinases phosphorylate Nrf2 to modulate its stability and/or activity. • Phosphorylation regulation of NRF2 bridges NRF2 activity to a series of biological events. • Targeting NRF2 phosphorylation regulation shows therapeutic potential for multiple inflammation-related diseases." @default.
- W3148503912 created "2021-04-13" @default.
- W3148503912 creator A5000372945 @default.
- W3148503912 creator A5054513101 @default.
- W3148503912 creator A5081678793 @default.
- W3148503912 creator A5082916154 @default.
- W3148503912 creator A5083013565 @default.
- W3148503912 date "2021-05-01" @default.
- W3148503912 modified "2023-09-29" @default.
- W3148503912 title "Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications" @default.
- W3148503912 cites W1157059961 @default.
- W3148503912 cites W1166587220 @default.
- W3148503912 cites W1483046275 @default.
- W3148503912 cites W1511492934 @default.
- W3148503912 cites W1526037649 @default.
- W3148503912 cites W1531386034 @default.
- W3148503912 cites W1785455093 @default.
- W3148503912 cites W1950405118 @default.
- W3148503912 cites W1964346504 @default.
- W3148503912 cites W1967135427 @default.
- W3148503912 cites W1968156654 @default.
- W3148503912 cites W1969375092 @default.
- W3148503912 cites W1973141016 @default.
- W3148503912 cites W1974456334 @default.
- W3148503912 cites W1975940353 @default.
- W3148503912 cites W1980739328 @default.
- W3148503912 cites W1986503768 @default.
- W3148503912 cites W1988593777 @default.
- W3148503912 cites W1989512556 @default.
- W3148503912 cites W1990561391 @default.
- W3148503912 cites W1990598806 @default.
- W3148503912 cites W1991265255 @default.
- W3148503912 cites W1991631628 @default.
- W3148503912 cites W1992692192 @default.
- W3148503912 cites W1993511165 @default.
- W3148503912 cites W1995633773 @default.
- W3148503912 cites W1999148207 @default.
- W3148503912 cites W1999273706 @default.
- W3148503912 cites W1999872962 @default.
- W3148503912 cites W2001094165 @default.
- W3148503912 cites W2006569015 @default.
- W3148503912 cites W2007143913 @default.
- W3148503912 cites W2019835347 @default.
- W3148503912 cites W2020681473 @default.
- W3148503912 cites W2021526208 @default.
- W3148503912 cites W2022879400 @default.
- W3148503912 cites W2024494094 @default.
- W3148503912 cites W2025286289 @default.
- W3148503912 cites W2029589188 @default.
- W3148503912 cites W2030386807 @default.
- W3148503912 cites W2034788880 @default.
- W3148503912 cites W2035676834 @default.
- W3148503912 cites W2038256325 @default.
- W3148503912 cites W2038500334 @default.
- W3148503912 cites W2038582574 @default.
- W3148503912 cites W2038612772 @default.
- W3148503912 cites W2041813594 @default.
- W3148503912 cites W2043959412 @default.
- W3148503912 cites W2046422673 @default.
- W3148503912 cites W2048664325 @default.
- W3148503912 cites W2052548231 @default.
- W3148503912 cites W2053047691 @default.
- W3148503912 cites W2053063855 @default.
- W3148503912 cites W2058138221 @default.
- W3148503912 cites W2059201682 @default.
- W3148503912 cites W2059287089 @default.
- W3148503912 cites W2064634296 @default.
- W3148503912 cites W2069935365 @default.
- W3148503912 cites W2069962876 @default.
- W3148503912 cites W2070301412 @default.
- W3148503912 cites W2072424256 @default.
- W3148503912 cites W2073182272 @default.
- W3148503912 cites W2075266560 @default.
- W3148503912 cites W2076892771 @default.
- W3148503912 cites W2077852011 @default.
- W3148503912 cites W2078500257 @default.
- W3148503912 cites W2079473693 @default.
- W3148503912 cites W2080435498 @default.
- W3148503912 cites W2080671121 @default.
- W3148503912 cites W2084644507 @default.
- W3148503912 cites W2085201901 @default.
- W3148503912 cites W2089097264 @default.
- W3148503912 cites W2091673674 @default.
- W3148503912 cites W2092261702 @default.
- W3148503912 cites W2092482659 @default.
- W3148503912 cites W2093611899 @default.
- W3148503912 cites W2094957750 @default.
- W3148503912 cites W2098462984 @default.
- W3148503912 cites W2098725447 @default.
- W3148503912 cites W2107601804 @default.
- W3148503912 cites W2111623179 @default.
- W3148503912 cites W2112286580 @default.
- W3148503912 cites W2115338196 @default.
- W3148503912 cites W2116223499 @default.
- W3148503912 cites W2117800935 @default.
- W3148503912 cites W2118394016 @default.
- W3148503912 cites W2118898883 @default.
- W3148503912 cites W2120587833 @default.