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- W3148528917 abstract "SUMMARY Background: Fluoroquinolones are key second-line anti-tuberculosis drugs usually used in the treatment of patients with Multi-Drug Resistant Tuberculosis (MDR-TB). Anti-TB fluoroquinolones include ciprofloxacin, moxifloxacin, gatifloxacin (Gat), ofloxacin and levofloxacin. Resistance to one fluoroquinolone usually translates to resistance to the others in the group. Objective: To determine whether there is fluoroquinolone resistance in Mycobacterium tuberculosis strains isolated in Kenya. Design: A retrospective descriptive study involving archived strains from previous studies carried out at the Centre for Respiratory Diseases Research (CRDR), Kenya Medical Research Institute (KEMRI) between 2002 and 2007. Setting: CRDR, KEMRI. Methods: A total of 216 first-line Drug Susceptibility Testing (DST) pre-tested MTB strains were used including 78 resistant to one or more drugs, and randomly selected 138 susceptible to all four drugs. Of the 78 resistant strains, 25 were MDR-TB. The strains were subjected to drug susceptibility testing to Gat among other second-line drugs. Results: Of the 216 strains tested, 32 [32/216 (14.8%)] showed resistance to second-line drugs. Of these seven [7/32 (21.9%)] were fully resistant to Gat of which six [6/7 (85.7%)] were mono-resistant strains and one [1/7 (14.3%)] with combined resistance strain to Ethionamide. Four [4/25 (16%)] MDR-TB strains showed mono-resistance to Gat." @default.
- W3148528917 created "2021-04-13" @default.
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- W3148528917 date "2012-01-01" @default.
- W3148528917 modified "2023-09-26" @default.
- W3148528917 title "FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS STRAINS ISOLATED IN KENYA." @default.
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