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- W3148575257 abstract "BACKGROUNDPreconditioning with brief episodes of coronary artery occlusion reduces infarct size caused by subsequent sustained ischemia. However, the effects of preconditioning on the coronary vasculature are poorly understood. We sought to determine whether preconditioning would attenuate low reflow (ie, the deterioration in resting myocardial perfusion) and blunt the loss in coronary vasodilator reserve after sustained occlusion/reperfusion in the anesthetized open-chest canine model.METHODS AND RESULTSThirty-two dogs underwent 1 hour of sustained left anterior descending (LAD) coronary artery occlusion and 4 hours of reperfusion. Each dog was randomly assigned to the preconditioned group (four episodes of 5 minutes of LAD occlusion plus 5 minutes of reperfusion before sustained ischemia) or control group (no intervention). Submaximal vasodilator reserve was determined by measuring the increase in CBF in response to 0.01 mg acetylcholine (an endothelium-dependent dilator) and 0.05 mg nitroglycerin (..." @default.
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- W3148575257 date "1993-01-01" @default.
- W3148575257 modified "2023-09-23" @default.
- W3148575257 title "Does preconditioning protect the coronary vasculature from subsequent ischemia/reperfusion injury?" @default.
- W3148575257 hasPublicationYear "1993" @default.
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