FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148575392> ?p ?o ?g. }

• W3148575392 endingPage "1157" @default.
• W3148575392 startingPage "1147" @default.
• W3148575392 abstract "Lipid droplets (LDs) are neutral lipid-containing organelles enclosed in a single monolayer of phospholipids. LD formation begins with the accumulation of neutral lipids within the bilayer of the endoplasmic reticulum (ER) membrane. It is not known how the sites of formation of nascent LDs in the ER membrane are determined. Here we show that multiple C2 domain-containing transmembrane proteins, MCTP1 and MCTP2, are at sites of LD formation in specialized ER subdomains. We show that the transmembrane domain (TMD) of these proteins is similar to a reticulon homology domain. Like reticulons, these proteins tubulate the ER membrane and favor highly curved regions of the ER. Our data indicate that the MCTP TMDs promote LD biogenesis, increasing LD number. MCTPs colocalize with seipin, a protein involved in LD biogenesis, but form more stable microdomains in the ER. The MCTP C2 domains bind charged lipids and regulate LD size, likely by mediating ER-LD contact sites. Together, our data indicate that MCTPs form microdomains within ER tubules that regulate LD biogenesis, size, and ER-LD contacts. Interestingly, MCTP punctae colocalized with other organelles as well, suggesting that these proteins may play a general role in linking tubular ER to organelle contact sites." @default.
• W3148575392 created "2021-04-13" @default.
• W3148575392 creator A5024471814 @default.
• W3148575392 creator A5039218520 @default.
• W3148575392 creator A5039961001 @default.
• W3148575392 creator A5082030725 @default.
• W3148575392 date "2021-06-01" @default.
• W3148575392 modified "2023-09-29" @default.
• W3148575392 title "Multiple C2 domain–containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains" @default.
• W3148575392 cites W1854421050 @default.
• W3148575392 cites W1977689678 @default.
• W3148575392 cites W1981049765 @default.
• W3148575392 cites W1984592684 @default.
• W3148575392 cites W1991180491 @default.
• W3148575392 cites W2009038548 @default.
• W3148575392 cites W2043312574 @default.
• W3148575392 cites W2086072764 @default.
• W3148575392 cites W2093883442 @default.
• W3148575392 cites W2096961333 @default.
• W3148575392 cites W2097275712 @default.
• W3148575392 cites W2115987666 @default.
• W3148575392 cites W2117112155 @default.
• W3148575392 cites W2121233961 @default.
• W3148575392 cites W2124733101 @default.
• W3148575392 cites W2136238917 @default.
• W3148575392 cites W2136338518 @default.
• W3148575392 cites W2160973386 @default.
• W3148575392 cites W2168135619 @default.
• W3148575392 cites W2168734886 @default.
• W3148575392 cites W2177040066 @default.
• W3148575392 cites W2343186052 @default.
• W3148575392 cites W2343212594 @default.
• W3148575392 cites W2509246155 @default.
• W3148575392 cites W2552567900 @default.
• W3148575392 cites W2553947326 @default.
• W3148575392 cites W2617667835 @default.
• W3148575392 cites W2735728316 @default.
• W3148575392 cites W2738028131 @default.
• W3148575392 cites W2743619083 @default.
• W3148575392 cites W2794331279 @default.
• W3148575392 cites W2804637674 @default.
• W3148575392 cites W2883311779 @default.
• W3148575392 cites W2891950607 @default.
• W3148575392 cites W2903107073 @default.
• W3148575392 cites W2913478135 @default.
• W3148575392 cites W2938832312 @default.
• W3148575392 cites W2947151227 @default.
• W3148575392 cites W2948599323 @default.
• W3148575392 cites W2949204612 @default.
• W3148575392 cites W2962450938 @default.
• W3148575392 cites W2981583844 @default.
• W3148575392 cites W2982080052 @default.
• W3148575392 cites W2988365714 @default.
• W3148575392 cites W3017170091 @default.
• W3148575392 cites W3019317568 @default.
• W3148575392 cites W3028511910 @default.
• W3148575392 cites W3043777212 @default.
• W3148575392 doi "https://doi.org/10.1091/mbc.e20-09-0590" @default.
• W3148575392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8351558" @default.
• W3148575392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33826368" @default.
• W3148575392 hasPublicationYear "2021" @default.
• W3148575392 type Work @default.
• W3148575392 sameAs 3148575392 @default.
• W3148575392 citedByCount "18" @default.
• W3148575392 countsByYear W31485753922021 @default.
• W3148575392 countsByYear W31485753922022 @default.
• W3148575392 countsByYear W31485753922023 @default.
• W3148575392 crossrefType "journal-article" @default.
• W3148575392 hasAuthorship W3148575392A5024471814 @default.
• W3148575392 hasAuthorship W3148575392A5039218520 @default.
• W3148575392 hasAuthorship W3148575392A5039961001 @default.
• W3148575392 hasAuthorship W3148575392A5082030725 @default.
• W3148575392 hasBestOaLocation W31485753921 @default.
• W3148575392 hasConcept C104317684 @default.
• W3148575392 hasConcept C118892022 @default.
• W3148575392 hasConcept C131934819 @default.
• W3148575392 hasConcept C139447449 @default.
• W3148575392 hasConcept C144647389 @default.
• W3148575392 hasConcept C155432671 @default.
• W3148575392 hasConcept C158617107 @default.
• W3148575392 hasConcept C161200384 @default.
• W3148575392 hasConcept C168240541 @default.
• W3148575392 hasConcept C170493617 @default.
• W3148575392 hasConcept C24530287 @default.
• W3148575392 hasConcept C41625074 @default.
• W3148575392 hasConcept C55493867 @default.
• W3148575392 hasConcept C86803240 @default.
• W3148575392 hasConcept C88020867 @default.
• W3148575392 hasConcept C95444343 @default.
• W3148575392 hasConceptScore W3148575392C104317684 @default.
• W3148575392 hasConceptScore W3148575392C118892022 @default.
• W3148575392 hasConceptScore W3148575392C131934819 @default.
• W3148575392 hasConceptScore W3148575392C139447449 @default.
• W3148575392 hasConceptScore W3148575392C144647389 @default.
• W3148575392 hasConceptScore W3148575392C155432671 @default.
• W3148575392 hasConceptScore W3148575392C158617107 @default.
• W3148575392 hasConceptScore W3148575392C161200384 @default.
• W3148575392 hasConceptScore W3148575392C168240541 @default.

• next