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- W3148581824 abstract "The aim of this study was to clarify determi- nants of glycemic variability in Japanese patients with diabetes. We performed continuous glucose monitoring (CGM) for 2-4 days in 88 patients with diabetes admitted to our hospital for poor glycemic control (20 with type 1 and 68 with type 2 diabetes). Glycemic variability was assessed by standard deviation (SD) of glucose and mean amplitude of glycemic excursions (MAGE) calculated from CGM data, and its relations to clinical parameters were investigated. Beta-cell function was assessed by serum C-peptide immunoreactivity (CPR) to glucose ratio (CPR index). As a result, glycemic variability was signif- icantly greater in patients with type 1 diabetes than in those with type 2 diabetes. In all patients, the glycated albumin to HbA1c ratio (GA/HbA1c) was positively correlated and the postprandial CPR index was negatively correlated with SD and MAGE (both p 0.05). In patients with type 2 dia- betes, age, diabetes duration, and GA/HbA1c were signif- icantly positively correlated with SD and MAGE, while multivariate analysis suggested that age and diabetes duration are the major determinants of glycemic variabil- ity. In conclusion, while glycemic variability was greater in patients with type 1 diabetes than those with type 2 dia- betes, age, diabetes duration, GA/HbA1c, and beta-cell function were associated with glycemic variability in Japanese patients with diabetes." @default.
- W3148581824 created "2021-04-13" @default.
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- W3148581824 date "2014-01-01" @default.
- W3148581824 modified "2023-09-27" @default.
- W3148581824 title "Factors associated with glycemic variability in Japanese patients with diabetes" @default.
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