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- W3148595444 abstract "N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are the main readers of m6A modification. YTH family proteins perform different functions to determine the metabolic fate of m6A-modified RNA. The crystal structure of the YTH domain has been completely resolved, highlighting the important roles of several conserved residues of the YTH domain in the specific recognition of m6A-modified RNAs. Upstream and downstream targets have been successively revealed in different cancer types and the role of YTH family proteins has been emphasized in m6A research. This review describes the regulation of RNAs by YTH family proteins, the structural features of the YTH domain, and the connections of YTH family proteins with human cancers." @default.
- W3148595444 created "2021-04-13" @default.
- W3148595444 creator A5010566551 @default.
- W3148595444 creator A5014471505 @default.
- W3148595444 creator A5021769901 @default.
- W3148595444 creator A5076943977 @default.
- W3148595444 creator A5078313825 @default.
- W3148595444 creator A5079202247 @default.
- W3148595444 date "2021-04-01" @default.
- W3148595444 modified "2023-10-06" @default.
- W3148595444 title "Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics" @default.
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