Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148609706> ?p ?o ?g. }
- W3148609706 abstract "Multivalent display of receptor-engaging antibodies or ligands can enhance their activity. Instead of achieving multivalency by attachment to preexisting scaffolds, here we unite form and function by the computational design of nanocages in which one structural component is an antibody or Fc-ligand fusion and the second is a designed antibody-binding homo-oligomer that drives nanocage assembly. Structures of eight nanocages determined by electron microscopy spanning dihedral, tetrahedral, octahedral, and icosahedral architectures with 2, 6, 12, and 30 antibodies per nanocage, respectively, closely match the corresponding computational models. Antibody nanocages targeting cell surface receptors enhance signaling compared with free antibodies or Fc-fusions in death receptor 5 (DR5)-mediated apoptosis, angiopoietin-1 receptor (Tie2)-mediated angiogenesis, CD40 activation, and T cell proliferation. Nanocage assembly also increases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudovirus neutralization by α-SARS-CoV-2 monoclonal antibodies and Fc-angiotensin-converting enzyme 2 (ACE2) fusion proteins." @default.
- W3148609706 created "2021-04-13" @default.
- W3148609706 creator A5002836913 @default.
- W3148609706 creator A5008619815 @default.
- W3148609706 creator A5010062468 @default.
- W3148609706 creator A5013243779 @default.
- W3148609706 creator A5013668335 @default.
- W3148609706 creator A5014867478 @default.
- W3148609706 creator A5016788401 @default.
- W3148609706 creator A5016851342 @default.
- W3148609706 creator A5021769285 @default.
- W3148609706 creator A5021781776 @default.
- W3148609706 creator A5021999547 @default.
- W3148609706 creator A5024950776 @default.
- W3148609706 creator A5025168390 @default.
- W3148609706 creator A5034137050 @default.
- W3148609706 creator A5039409164 @default.
- W3148609706 creator A5040945502 @default.
- W3148609706 creator A5049261929 @default.
- W3148609706 creator A5049713027 @default.
- W3148609706 creator A5050073558 @default.
- W3148609706 creator A5050329644 @default.
- W3148609706 creator A5053192926 @default.
- W3148609706 creator A5055284343 @default.
- W3148609706 creator A5063114631 @default.
- W3148609706 creator A5070045357 @default.
- W3148609706 creator A5075885740 @default.
- W3148609706 creator A5077626799 @default.
- W3148609706 creator A5081264094 @default.
- W3148609706 creator A5085406779 @default.
- W3148609706 creator A5086820622 @default.
- W3148609706 creator A5090870055 @default.
- W3148609706 date "2021-04-02" @default.
- W3148609706 modified "2023-10-02" @default.
- W3148609706 title "Designed proteins assemble antibodies into modular nanocages" @default.
- W3148609706 cites W150762677 @default.
- W3148609706 cites W1861441728 @default.
- W3148609706 cites W1898469614 @default.
- W3148609706 cites W1976603396 @default.
- W3148609706 cites W1985796689 @default.
- W3148609706 cites W2003649034 @default.
- W3148609706 cites W2004663239 @default.
- W3148609706 cites W2011881868 @default.
- W3148609706 cites W2012778514 @default.
- W3148609706 cites W2022265958 @default.
- W3148609706 cites W2031420717 @default.
- W3148609706 cites W2054770020 @default.
- W3148609706 cites W2075824676 @default.
- W3148609706 cites W2076449818 @default.
- W3148609706 cites W2079766756 @default.
- W3148609706 cites W2081826205 @default.
- W3148609706 cites W2084376588 @default.
- W3148609706 cites W2088729407 @default.
- W3148609706 cites W2092220359 @default.
- W3148609706 cites W2098182642 @default.
- W3148609706 cites W2105951661 @default.
- W3148609706 cites W2106246537 @default.
- W3148609706 cites W2106937142 @default.
- W3148609706 cites W2123232632 @default.
- W3148609706 cites W2151266657 @default.
- W3148609706 cites W2152562710 @default.
- W3148609706 cites W2159862555 @default.
- W3148609706 cites W2161661741 @default.
- W3148609706 cites W2170682201 @default.
- W3148609706 cites W2199134476 @default.
- W3148609706 cites W2269706424 @default.
- W3148609706 cites W2290145688 @default.
- W3148609706 cites W2433987067 @default.
- W3148609706 cites W2491008760 @default.
- W3148609706 cites W2505717465 @default.
- W3148609706 cites W2559856762 @default.
- W3148609706 cites W2570252136 @default.
- W3148609706 cites W2587625522 @default.
- W3148609706 cites W2606133995 @default.
- W3148609706 cites W2616918494 @default.
- W3148609706 cites W2785721281 @default.
- W3148609706 cites W2791354025 @default.
- W3148609706 cites W2804037854 @default.
- W3148609706 cites W2892223298 @default.
- W3148609706 cites W2896592874 @default.
- W3148609706 cites W2898721059 @default.
- W3148609706 cites W2922684595 @default.
- W3148609706 cites W2944245644 @default.
- W3148609706 cites W2945929016 @default.
- W3148609706 cites W2950967305 @default.
- W3148609706 cites W2977933365 @default.
- W3148609706 cites W2999958881 @default.
- W3148609706 cites W3009335299 @default.
- W3148609706 cites W3019957468 @default.
- W3148609706 cites W3020828664 @default.
- W3148609706 cites W3023698680 @default.
- W3148609706 cites W3025744748 @default.
- W3148609706 cites W3033450058 @default.
- W3148609706 cites W3042931923 @default.
- W3148609706 cites W3047128047 @default.
- W3148609706 cites W3086125063 @default.
- W3148609706 cites W3087678237 @default.
- W3148609706 cites W3089112814 @default.
- W3148609706 cites W3093371139 @default.
- W3148609706 cites W3165324426 @default.