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- W3148620281 abstract "Objective Screening and characterizing high affinity completely humanized single-chain antibody(ScFv) against PreS 1 of hepatitis B virus. Methods A combinatorial library of phage-displayed human ScFv, genes of which were derived from peripheral blood lymphocytes immunized by PreS1 of Hepatitis B Virus in vitro, was constructed. The library contained 7 × 108 clones. Results After 3 rounds panning, a high affinity (K = 107 ~ 108 mol/L) ScFv specific to PreS1 was obtained. The VH belonged to human VH4 family, and Vλ to Vλ4 by sequence analysis. Conclusions This study suggests that the method of antigen stimulation in vitro is an expeditious way for the source of human immune antibody. And the ScFv may provide a more satisfactory therapy." @default.
- W3148620281 created "2021-04-13" @default.
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- W3148620281 date "2003-01-01" @default.
- W3148620281 modified "2023-09-26" @default.
- W3148620281 title "Generation of high affinity humanized single-chain antibody against PreS1 of hepatitis B virus from immune phage displayed antibody library" @default.
- W3148620281 hasPublicationYear "2003" @default.
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