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- W3148663295 abstract "Interleukin-2 (IL-2 ) 是一个重要 immunoregulatory 因素。在在 IL-2 和它的受体之间的相互作用以后，细胞内部的信号分子被激活并且 pro-oncogenes， e.g.c-Myc， c-Fos， c6 月 andBcl-2 被导致，然后，与 IL-2 刺激的房间将增殖或区分。在这些过程期间， IL-2 被使内在化。IL-2 的成为主观由 IL-2R 减少调停了房间膜上的 IL-2R 的数字，并且让细胞外的 IL-2 进入房间并且降级。它愿望下面调整 IL-2 生物活动。为了从各种各样的 IL-2R 识别为 IL-2 成为主观，由不同 endocellular 领域组成了的妄想的 IL-2Rs 和细胞外的领域负责的 IL-2R 子单元，子单元被构造。在他们是进 L929 房间线的 transfected 以后， IL-2 成为主观被检测。结果显示出那从 IL-2R 的细胞内部的领域 and 尾 subunlts 不能调停 IL-2 成为主观独自一个；为 IL-2 成为主观的信号仅仅位于 IL-2R 纬子单元的 endocellular 域。而且， IL-2 成为主观程度将被与 IL-2 和 IL-2R 的亲密关系影响。" @default.
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- W3148663295 date "1998-01-01" @default.
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- W3148663295 title "Signal for IL-2 internalization located in the endocellular domain of IL-2R γ subunit only" @default.
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