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- W3148671565 abstract "The P68 nuclear protein is an ATP-dependent RNA helicase a nd RNA-dependent ATPase, and has been proved to have functions in the regulati on o f cell growth and division. Different phenotypes of P68 between tumouric cell li nes (HeLa, TC 3H 10) and non-tumouric cell lines (NIH3T3 and NC 3H 10 ) were observed, and we reasoned that overexpression of P68 might profoundly a ffect cellular growth properties. We report here that overexpression human P68 b y transfection of recombinant P68 expression vector in NIH3T3 and NC 3H 10 fibroblasts causes their tumorigenic transformation as determined by four crite ria:(1) the morphology of transfectants from long fibric to spindle shaped; (2) formation of transformed foci on the monolayer of cells; (3) the transfectants a cquired the ability to grow on soft agar forming cell microsphere cube; (4) tumo r formation in nude mice after injection of transfected cells for 3～4 weeks." @default.
- W3148671565 created "2021-04-13" @default.
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- W3148671565 date "2001-01-01" @default.
- W3148671565 modified "2023-09-25" @default.
- W3148671565 title "The Study of P68 RNA Helicase on Cell Transformaion" @default.
- W3148671565 hasPublicationYear "2001" @default.
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