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- W3148690505 abstract "Background: The advent of induced pluripotent stem (iPS) cells has introduced an alternative to the use of embryonic stem cells for tissue regeneration. iPS cells are associated with fewer technical limitations and ethical controversy. Moreover, potential use of autologous cells for patient-specific therapies makes these reprogrammed cells an attractive vehicle for regenerative therapies. Despite great advances and clear clinical advantages over ES cells, iPS cell technology is still in its early development, and research focuses on adjusting the mechanism of reprogramming to optimize the use of these cells. The Problem: How can we translate what we know about these cells, based on in vitro data to practical, clinical applications? How can we optimize the safety, completeness, and efficiency of reprogramming? How can we address the limitations to the clinical use of these cells (such as teratoma development)? Basic/Clinical Science Advances: Introduction of four key transcription factors using viral vectors were used to reprogram murine and adult human fibrobroblasts and human fetal, neonatal, and adult primary cells to pluripotency. Clinical Care Relevance: The projected use of these cells could enhance the speed at which wounds heal and improve the appearance of scars. Conclusion: Further delineation of the mechanisms involved in reprogramming will provide insight into how the process could be altered to improve safety and efficiency. The introduction of direct programming is an exciting advance that could eliminate the risk of teratoma development, as well as make iPS cells more suitable for clinical applications." @default.
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- W3148690505 date "2011-01-01" @default.
- W3148690505 modified "2023-09-27" @default.
- W3148690505 title "Induced Pluripotent Stem Cells" @default.
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