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- W3148697997 abstract "A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs （miRNAs）, their growth factors and their downstreamagents is required for the initiation and completion ofpathogenesis in the liver. miRNAs are thought to exert aprofound effect on almost every aspect of liver biologyand pathology. Accumulating evidence indicates thatseveral miRNAs are involved in the hepatitis B virus（HBV） life cycle and infectivity, in addition to HBVassociatedliver diseases including fibrosis, cirrhosisand hepatocellular carcinoma （HCC）. In turn, HBV canmodulate the expression of several cellular miRNAs, thuspromoting a favorable environment for its replicationand survival. In this review, we focused on the involvementof host cellular miRNAs that are directly andindirectly associated with HBV RNA or HBV associatedtranscription factors. Exploring different facets of theinteractions among miRNA, HBV and HCV infections, andthe carcinogenesis and progress of HCC, could facilitatethe development of novel and effective treatmentapproaches for liver disease." @default.
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- W3148697997 date "2015-01-01" @default.
- W3148697997 modified "2023-09-23" @default.
- W3148697997 title "Host cellular microRNA involvement in the control ofhepatitis B virus gene expression and replication" @default.
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