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- W3148701510 abstract "Genetics is a powerful tool for studying the function of different gene products as well as the physiological consequences of a normal or aberrant polypeptide. Until recently, the most powerful genetic applications have been restricted to relatively simple organisms whose genomes are more easily manipulated. For a number of years, in lower organisms, it has been possible to create defined genetic changes that are targeted to a specific locus or even to a defined codon or transcriptional regulatory sequence. With the development of gene targeting using embryonic stem cells derived from the preimplantation blastocyst of a mouse, it has become possible to extend these experiments to a mammalian system. Via homologous recombination, one can ablate, or knock out, a defined genetic locus or mutate a particular set of nucleotides that encodes a peptide domain of interest. These techniques, when applied to genes that underlie normal cardiovascular function, promise to define the exact role(s) different proteins..." @default.
- W3148701510 created "2021-04-13" @default.
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- W3148701510 date "1993-01-01" @default.
- W3148701510 modified "2023-09-24" @default.
- W3148701510 title "Gene targeting. The precise manipulation of the mammalian genome." @default.
- W3148701510 hasPublicationYear "1993" @default.
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