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- W3148718678 abstract "Tumor necrosis factor receptor-associated fac- tor 4 (TRAF4) is upregulated in various subtypes of breast cancers and cell lines; however, the precise functions of TRAF4 are poorly understood. Our objective was to investigate its relationship with b-catenin. TRAF4 partici- pates in several signaling pathways, such as NF-jB and JNK signaling pathways. In this study, we identified b- catenin as a TRAF4-binding protein, have shown that TRAF4 enhanced expression of b-catenin, and found that TRAF4 mediated the translocation of b-catenin from the cytoplasm to the nucleus, thereby facilitating activation of the Wnt signaling pathway in breast cancer." @default.
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- W3148718678 date "2014-01-01" @default.
- W3148718678 modified "2023-09-26" @default.
- W3148718678 title "TRAF4 participates in Wnt/b-catenin signaling in breast cancer by upregulating b-catenin and mediating its translocation to the nucleus" @default.
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