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- W3148778856 abstract "The reproductive process is an inefficient one, and there is a considerable amount of fctal wastage in a variety of species. This phenomenon had been best studied in the human, rat, and mouse: 48% to 74% of human conceptuses are lost (4); in rats bearing the major histocompatibility complex (M HC)-linkcd grc genes, 20% to 25% of grc homozygotes die in the immediate poslnalai period (15); and in the CBA x DBAI2 mating combination in mice, approximately 30% of the conceptuses abort sponlaneous]y (1, 13), We have tried to organize the various immunological and genetic faewrs Ihal influence reproduction into an integrated hypothesis that focuses primarily on the effects of MHC and MHClinked genes (5,6). This hypothesis is outlined in Figure 15.1. The most important facwr in the conlTol of normal fe lal development is genet ic compatibility between the mating partners. Once this crit ical condit ion has been met, a variety of immunological facwrs may modulate the implantation process under certain conditions. Genetic compatibility requires that the mating partners contribute no recessive lethal genes that could act alone orepistatically in the developing felUs. The immunological response in normal pregnancies is not destructive. because it is not directed against the classical class I transplantation antigens but rather against a unique placental class I antigen(s) that has broadly shared (public) specificit ies only and not haplotype-specifi c (private) specifici ties. In the cases where immunological modulation has been shown to affect implantation , the mechanisms are not yet known. In humans, women who lose their conceptuses without forming antipaternal antibodies may do so because of the primary action of recessive lethal or semilethal genes. In women who lose their conceptuses and who make lymphocytotoxic antibodies directed against paternal antigens, the mechanism for repressing the expression of the classical class I transplantat ion antigens on the placental surface may be defective. These transplantation antigens would then elicit a destructive immune response that would lead to spontaneous abortion. There is some ev idence from animal studies and from cl inical observations that the genes affecting embryological development may also lead to the development of congenital anomal ies and to an increased suscept ibi li ty to cancer." @default.
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- W3148778856 date "2011-01-01" @default.
- W3148778856 modified "2023-09-23" @default.
- W3148778856 title "Immunogenetic Control of Pregnancy and Development" @default.
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