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- W3148779616 abstract "This review gives a broad overview of the key factors of ischemic injury to the liver and presents the current modifications of preservation solutions and the few strategies of biological modulation in clinical use today.Protective effects in human-liver transplantation were shown by methylprednisolone treatment in decreased donors, and by inhalation of a nontoxic dose of nitric oxide in recipients. In addition, recent results showed rescue of pig livers, donated after cardiac death by application of a cocktail of substances addressing several previously identified mechanisms of ischemia-reperfusion injury.The future of a pharmacological approach attenuating or preventing ischemia-reperfusion injury lies in a combination of drugs acting simultaneously on several steps of the injury cascades. Applying these substances during flush, before, and during implantation appears as an attractive strategy to protect extended criteria liver grafts." @default.
- W3148779616 created "2021-04-13" @default.
- W3148779616 creator A5074488110 @default.
- W3148779616 creator A5078241279 @default.
- W3148779616 creator A5081244573 @default.
- W3148779616 date "2010-04-01" @default.
- W3148779616 modified "2023-10-17" @default.
- W3148779616 title "Biological modulation of liver ischemia–reperfusion injury" @default.
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- W3148779616 doi "https://doi.org/10.1097/mot.0b013e3283373ced" @default.
- W3148779616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20125019" @default.
- W3148779616 hasPublicationYear "2010" @default.
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