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- W3148788044 abstract "Migraine is one of the most common of neurological disorders with a global prevalence of up to 15%. One in five migraineurs have frequent episodic or chronic migraine requiring prophylactic treatment. In recent years, specific pharmacological treatments targeting calcitonin gene-related peptide (CGRP) signalling molecules have provided safe and effective treatments, monoclonal antibodies for prophylaxis and gepants for acute therapy. Albeit beneficial, it is important to understand the molecular mechanisms of these new drugs to better understand migraine pathophysiology and improve therapy. Here, we describe current views on the role of the CGRP family of peptides - CGRP, calcitonin, adrenomedullin, amylin - and their receptors in the trigeminovascular system. All these molecules are present within the trigeminovascular system but differ in expression and localization. It is likely that they have different roles, which can be utilized in providing additional drug targets. LINKED ARTICLES: This article is part of a themed issue on Advances in Migraine and Headache Therapy (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.3/issuetoc." @default.
- W3148788044 created "2021-04-13" @default.
- W3148788044 creator A5048776295 @default.
- W3148788044 creator A5084413123 @default.
- W3148788044 creator A5085116945 @default.
- W3148788044 date "2021-10-07" @default.
- W3148788044 modified "2023-10-12" @default.
- W3148788044 title "Biological and small molecule strategies in migraine therapy with relation to the calcitonin gene‐related peptide family of peptides" @default.
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- W3148788044 doi "https://doi.org/10.1111/bph.15669" @default.
- W3148788044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34411289" @default.
- W3148788044 hasPublicationYear "2021" @default.
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