Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148799152> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3148799152 endingPage "860" @default.
- W3148799152 startingPage "855" @default.
- W3148799152 abstract "AIM To evaluate the potential of RA-538 genetherapy for gastric carcinoma.METHODS Human gastric carcinoma cell lineSGC7901 treated with Ad-RA538 or Ad-LacZ wereanalysed by X-gal stain,MTT,DNA ladder,Tunel,flow cytometric analysis,PCR,andWestern Blot in vitro.The tumorigenicity andexperimental therapy in nude mice model wereassessed in vivo.RESULTS Ad-LacZ could efficiently transferthe LacZ gene into SGC7901 cells.X-gal-positivecells at MOI 25,50,100,and 200 were 90%,100%,100%,and 100% respectively.Ad-RA538could strongly inhibit cell growth and inducedapoptosis in SGC7901 cells.The proliferation ofthe Ad-RA538-infected SGC7901 cells wasreduced by 76.3%.The mechanism of killing ofgastric carcinoma cells by Ad-RA538 was foundto be apoptosis by DNA ladder,Tunel and flowcytometric analysis.The tumorigenicity in nudemice using Ad-RA538 showed that all three micefailed to form tumor from 7 to 30 days comparedwith Ad-LacZ and parent SGC7901 cells.Experimental therapy on the nude mice modelbearing subcutaneous tumor of SGC790| cells showed that intratumor instillation of Ad-RA538inhibited the growth of the tumors.Ad-RA538-treated tumors were inhibited by 60.66 %,compared with that of the tumor injected withAd-LacZ and mock.CONCLUSION The expression of Ad-RA538 can inhibit growth and induce apoptosis of gastric cancer cell in vitro and in vivo. Ad-RA538 can be used potentially in gene therapy for gastric carcinoma." @default.
- W3148799152 created "2021-04-13" @default.
- W3148799152 creator A5001978013 @default.
- W3148799152 creator A5030573266 @default.
- W3148799152 creator A5031574504 @default.
- W3148799152 creator A5031774992 @default.
- W3148799152 creator A5036457690 @default.
- W3148799152 creator A5068607867 @default.
- W3148799152 date "2000-01-01" @default.
- W3148799152 modified "2023-09-23" @default.
- W3148799152 title "The therapeutic effects of recombinant adenovirus RA538 on human gastric carcinoma cells in vitro and in vivo" @default.
- W3148799152 hasPublicationYear "2000" @default.
- W3148799152 type Work @default.
- W3148799152 sameAs 3148799152 @default.
- W3148799152 citedByCount "0" @default.
- W3148799152 crossrefType "journal-article" @default.
- W3148799152 hasAuthorship W3148799152A5001978013 @default.
- W3148799152 hasAuthorship W3148799152A5030573266 @default.
- W3148799152 hasAuthorship W3148799152A5031574504 @default.
- W3148799152 hasAuthorship W3148799152A5031774992 @default.
- W3148799152 hasAuthorship W3148799152A5036457690 @default.
- W3148799152 hasAuthorship W3148799152A5068607867 @default.
- W3148799152 hasConcept C104317684 @default.
- W3148799152 hasConcept C111599444 @default.
- W3148799152 hasConcept C121608353 @default.
- W3148799152 hasConcept C142724271 @default.
- W3148799152 hasConcept C1491633281 @default.
- W3148799152 hasConcept C150903083 @default.
- W3148799152 hasConcept C153911025 @default.
- W3148799152 hasConcept C190283241 @default.
- W3148799152 hasConcept C196795494 @default.
- W3148799152 hasConcept C202751555 @default.
- W3148799152 hasConcept C207001950 @default.
- W3148799152 hasConcept C2777546739 @default.
- W3148799152 hasConcept C2780278673 @default.
- W3148799152 hasConcept C2780783641 @default.
- W3148799152 hasConcept C502942594 @default.
- W3148799152 hasConcept C54355233 @default.
- W3148799152 hasConcept C553184892 @default.
- W3148799152 hasConcept C55493867 @default.
- W3148799152 hasConcept C62112901 @default.
- W3148799152 hasConcept C71924100 @default.
- W3148799152 hasConcept C86803240 @default.
- W3148799152 hasConcept C96232424 @default.
- W3148799152 hasConceptScore W3148799152C104317684 @default.
- W3148799152 hasConceptScore W3148799152C111599444 @default.
- W3148799152 hasConceptScore W3148799152C121608353 @default.
- W3148799152 hasConceptScore W3148799152C142724271 @default.
- W3148799152 hasConceptScore W3148799152C1491633281 @default.
- W3148799152 hasConceptScore W3148799152C150903083 @default.
- W3148799152 hasConceptScore W3148799152C153911025 @default.
- W3148799152 hasConceptScore W3148799152C190283241 @default.
- W3148799152 hasConceptScore W3148799152C196795494 @default.
- W3148799152 hasConceptScore W3148799152C202751555 @default.
- W3148799152 hasConceptScore W3148799152C207001950 @default.
- W3148799152 hasConceptScore W3148799152C2777546739 @default.
- W3148799152 hasConceptScore W3148799152C2780278673 @default.
- W3148799152 hasConceptScore W3148799152C2780783641 @default.
- W3148799152 hasConceptScore W3148799152C502942594 @default.
- W3148799152 hasConceptScore W3148799152C54355233 @default.
- W3148799152 hasConceptScore W3148799152C553184892 @default.
- W3148799152 hasConceptScore W3148799152C55493867 @default.
- W3148799152 hasConceptScore W3148799152C62112901 @default.
- W3148799152 hasConceptScore W3148799152C71924100 @default.
- W3148799152 hasConceptScore W3148799152C86803240 @default.
- W3148799152 hasConceptScore W3148799152C96232424 @default.
- W3148799152 hasIssue "6" @default.
- W3148799152 hasLocation W31487991521 @default.
- W3148799152 hasOpenAccess W3148799152 @default.
- W3148799152 hasPrimaryLocation W31487991521 @default.
- W3148799152 hasRelatedWork W2008231487 @default.
- W3148799152 hasRelatedWork W2013159073 @default.
- W3148799152 hasRelatedWork W2101086499 @default.
- W3148799152 hasRelatedWork W2136639300 @default.
- W3148799152 hasRelatedWork W2324421972 @default.
- W3148799152 hasRelatedWork W2349950158 @default.
- W3148799152 hasRelatedWork W2358914604 @default.
- W3148799152 hasRelatedWork W2359358513 @default.
- W3148799152 hasRelatedWork W2364153516 @default.
- W3148799152 hasRelatedWork W2373624984 @default.
- W3148799152 hasRelatedWork W2379061736 @default.
- W3148799152 hasRelatedWork W2379717167 @default.
- W3148799152 hasRelatedWork W2381360837 @default.
- W3148799152 hasRelatedWork W2381891582 @default.
- W3148799152 hasRelatedWork W2385072623 @default.
- W3148799152 hasRelatedWork W2386608608 @default.
- W3148799152 hasRelatedWork W2405349092 @default.
- W3148799152 hasRelatedWork W2418945471 @default.
- W3148799152 hasRelatedWork W2333841779 @default.
- W3148799152 hasRelatedWork W3031700701 @default.
- W3148799152 isParatext "false" @default.
- W3148799152 isRetracted "false" @default.
- W3148799152 magId "3148799152" @default.
- W3148799152 workType "article" @default.