FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148850623> ?p ?o ?g. }

• W3148850623 abstract "SUMMARY The rapid spreading of the newly emerged SARS-CoV-2 variant, B.1.1.7, highlighted the requirements to better understand adaptive immune responses to this virus. Since CD8 + T cell responses play an important role in disease resolution and modulation in COVID-19 patients, it is essential to address whether these newly emerged mutations would result in altered immune responses. Here we evaluated the immune properties of the HLA-A2 restricted CD8 + T cell epitopes containing mutations from B.1.1.7, and furthermore performed a comprehensive analysis of the SARS-CoV-2 specific CD8 + T cell responses from COVID-19 convalescent patients and SARS-CoV-2 vaccinees recognizing the ancestral Wuhan strain compared to B.1.1.7. First, most of the predicted CD8 + T cell epitopes showed proper binding with HLA-A2, while epitopes from B.1.1.7 had lower binding capability than those from the ancestral strain. In addition, these peptides could effectively induced the activation and cytotoxicity of CD8 + T cells. Our results further showed that at least two site mutations in B.1.1.7 resulted in a decrease in CD8 + T cell activation and a possible immune evasion, namely A1708D mutation in ORF1ab 1707-1716 and I2230T mutation in ORF1ab 2230-2238 . Our current analysis provides information that contributes to the understanding of SARS-CoV-2-specific CD8 + T cell responses elicited by infection of mutated strains or vaccination. Graphical Abstract" @default.
• W3148850623 created "2021-04-13" @default.
• W3148850623 creator A5001949519 @default.
• W3148850623 creator A5008857498 @default.
• W3148850623 creator A5012229859 @default.
• W3148850623 creator A5024227599 @default.
• W3148850623 creator A5041218102 @default.
• W3148850623 creator A5041218363 @default.
• W3148850623 creator A5047580780 @default.
• W3148850623 creator A5049806666 @default.
• W3148850623 creator A5056158655 @default.
• W3148850623 creator A5057798666 @default.
• W3148850623 creator A5058184944 @default.
• W3148850623 creator A5072941689 @default.
• W3148850623 creator A5073137692 @default.
• W3148850623 creator A5074665620 @default.
• W3148850623 creator A5075426616 @default.
• W3148850623 creator A5087419694 @default.
• W3148850623 creator A5088091314 @default.
• W3148850623 creator A5090156292 @default.
• W3148850623 date "2021-03-29" @default.
• W3148850623 modified "2023-10-06" @default.
• W3148850623 title "SARS-CoV-2 variant B.1.1.7 caused HLA-A2⁺CD8⁺T cell epitope mutations for impaired cellular immune response" @default.
• W3148850623 cites W1768303176 @default.
• W3148850623 cites W2009483826 @default.
• W3148850623 cites W2885999655 @default.
• W3148850623 cites W3004896487 @default.
• W3148850623 cites W3025320502 @default.
• W3148850623 cites W3036551549 @default.
• W3148850623 cites W3037718428 @default.
• W3148850623 cites W3042183476 @default.
• W3148850623 cites W3043722389 @default.
• W3148850623 cites W3045971896 @default.
• W3148850623 cites W3049293761 @default.
• W3148850623 cites W3080524815 @default.
• W3148850623 cites W3090801115 @default.
• W3148850623 cites W3093824751 @default.
• W3148850623 cites W3109925330 @default.
• W3148850623 cites W3111019319 @default.
• W3148850623 cites W3111255098 @default.
• W3148850623 cites W3112108776 @default.
• W3148850623 cites W3113031614 @default.
• W3148850623 cites W3118443299 @default.
• W3148850623 cites W3118790515 @default.
• W3148850623 cites W3119231619 @default.
• W3148850623 cites W3119858919 @default.
• W3148850623 cites W3122458452 @default.
• W3148850623 cites W3123108673 @default.
• W3148850623 cites W3123339970 @default.
• W3148850623 cites W3130027029 @default.
• W3148850623 cites W3131938123 @default.
• W3148850623 cites W3132464854 @default.
• W3148850623 cites W3133789246 @default.
• W3148850623 cites W3134566701 @default.
• W3148850623 cites W3135671690 @default.
• W3148850623 doi "https://doi.org/10.1101/2021.03.28.437363" @default.
• W3148850623 hasPublicationYear "2021" @default.
• W3148850623 type Work @default.
• W3148850623 sameAs 3148850623 @default.
• W3148850623 citedByCount "1" @default.
• W3148850623 countsByYear W31488506232021 @default.
• W3148850623 crossrefType "posted-content" @default.
• W3148850623 hasAuthorship W3148850623A5001949519 @default.
• W3148850623 hasAuthorship W3148850623A5008857498 @default.
• W3148850623 hasAuthorship W3148850623A5012229859 @default.
• W3148850623 hasAuthorship W3148850623A5024227599 @default.
• W3148850623 hasAuthorship W3148850623A5041218102 @default.
• W3148850623 hasAuthorship W3148850623A5041218363 @default.
• W3148850623 hasAuthorship W3148850623A5047580780 @default.
• W3148850623 hasAuthorship W3148850623A5049806666 @default.
• W3148850623 hasAuthorship W3148850623A5056158655 @default.
• W3148850623 hasAuthorship W3148850623A5057798666 @default.
• W3148850623 hasAuthorship W3148850623A5058184944 @default.
• W3148850623 hasAuthorship W3148850623A5072941689 @default.
• W3148850623 hasAuthorship W3148850623A5073137692 @default.
• W3148850623 hasAuthorship W3148850623A5074665620 @default.
• W3148850623 hasAuthorship W3148850623A5075426616 @default.
• W3148850623 hasAuthorship W3148850623A5087419694 @default.
• W3148850623 hasAuthorship W3148850623A5088091314 @default.
• W3148850623 hasAuthorship W3148850623A5090156292 @default.
• W3148850623 hasBestOaLocation W31488506231 @default.
• W3148850623 hasConcept C104317684 @default.
• W3148850623 hasConcept C147483822 @default.
• W3148850623 hasConcept C154317977 @default.
• W3148850623 hasConcept C159047783 @default.
• W3148850623 hasConcept C159654299 @default.
• W3148850623 hasConcept C167672396 @default.
• W3148850623 hasConcept C188280979 @default.
• W3148850623 hasConcept C195616568 @default.
• W3148850623 hasConcept C202751555 @default.
• W3148850623 hasConcept C203014093 @default.
• W3148850623 hasConcept C2776090121 @default.
• W3148850623 hasConcept C2778453870 @default.
• W3148850623 hasConcept C501734568 @default.
• W3148850623 hasConcept C54355233 @default.
• W3148850623 hasConcept C86803240 @default.
• W3148850623 hasConcept C8891405 @default.
• W3148850623 hasConceptScore W3148850623C104317684 @default.
• W3148850623 hasConceptScore W3148850623C147483822 @default.
• W3148850623 hasConceptScore W3148850623C154317977 @default.

• next