Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148879332> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3148879332 abstract "BACKGROUND OBJECTIVE: X-ray repair cross complementing group 1 (XRCC1) encodes a protein required for DNA base excision repair and single strand break recombination repair. The polymorphisms of XRCC1 affect the function of the protein, therefore, affect the susceptibility of human to cancers. This population-based case-control study was to examine the correlations of the 3 most common single nucleotide polymorphisms (SNPs) of XRCC1 gene, C26304T, G27466A and G28152A, to risk of colorectal cancer. METHODS:XRCC1 genotypes in 207 colorectal cancer patients and 621 matched healthy controls were analyzed by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP). The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated using unconditional logistic regression model to evaluate the correlations of the 3 genotypes to risk of colorectal cancer. The haplotype distribution was estimated by EH linkage software 1.2. RESULTS: There was no significant differences in selected characteristics, such as age, sex, body mass index, cigarette-smoking and alcohol-drinking status, between the patients and the controls. The frequencies of mutant 26304T, 27466A, and 28152A alleles were 29.95%, 11.22%, and 28.22%, respectively, in the patients, and 32.87%, 12.34%, and 27.27%, respectively, in the controls; there was also no significant difference between the 2 groups. All the polymorphic genotypes met the Hardy-Weinberg equilibrium. No significant correlation of XRCC1 C26304T, G27466A, and G28152A polymorphisms to risk of colorectal cancer was found. Estimated by EH linkage software 1.2, genetic linkage disequilibrium existed both in the patients and the controls, and CGG, CGA, CAG, and TGG were the 4 most common haplotypes. However, there was no significant difference in haplotype distribution between the 2 groups (95.54% vs. 96.64%, P0.05). CONCLUSIONS: In Han people in southern China, XRCC1 C26304T, G27466A, and G28152A polymorphisms have no correlations to risk of colorectal cancer. However, the genetic linkage disequilibrium exists in these 3 polymorphic sites, and CGG, CGA, CAG, and TGG are the 4 most common haplotypes." @default.
- W3148879332 created "2021-04-13" @default.
- W3148879332 creator A5012904925 @default.
- W3148879332 date "2007-01-01" @default.
- W3148879332 modified "2023-09-23" @default.
- W3148879332 title "Correlations of Single Nucleotide Polymorphisms of DNA Repair Gene XRCC1 to Risk of Colorectal Cancer" @default.
- W3148879332 hasPublicationYear "2007" @default.
- W3148879332 type Work @default.
- W3148879332 sameAs 3148879332 @default.
- W3148879332 citedByCount "0" @default.
- W3148879332 crossrefType "journal-article" @default.
- W3148879332 hasAuthorship W3148879332A5012904925 @default.
- W3148879332 hasConcept C104317684 @default.
- W3148879332 hasConcept C121608353 @default.
- W3148879332 hasConcept C126322002 @default.
- W3148879332 hasConcept C135763542 @default.
- W3148879332 hasConcept C143998085 @default.
- W3148879332 hasConcept C153209595 @default.
- W3148879332 hasConcept C156957248 @default.
- W3148879332 hasConcept C180754005 @default.
- W3148879332 hasConcept C197754878 @default.
- W3148879332 hasConcept C2776999993 @default.
- W3148879332 hasConcept C35605836 @default.
- W3148879332 hasConcept C526805850 @default.
- W3148879332 hasConcept C54355233 @default.
- W3148879332 hasConcept C71924100 @default.
- W3148879332 hasConcept C86803240 @default.
- W3148879332 hasConceptScore W3148879332C104317684 @default.
- W3148879332 hasConceptScore W3148879332C121608353 @default.
- W3148879332 hasConceptScore W3148879332C126322002 @default.
- W3148879332 hasConceptScore W3148879332C135763542 @default.
- W3148879332 hasConceptScore W3148879332C143998085 @default.
- W3148879332 hasConceptScore W3148879332C153209595 @default.
- W3148879332 hasConceptScore W3148879332C156957248 @default.
- W3148879332 hasConceptScore W3148879332C180754005 @default.
- W3148879332 hasConceptScore W3148879332C197754878 @default.
- W3148879332 hasConceptScore W3148879332C2776999993 @default.
- W3148879332 hasConceptScore W3148879332C35605836 @default.
- W3148879332 hasConceptScore W3148879332C526805850 @default.
- W3148879332 hasConceptScore W3148879332C54355233 @default.
- W3148879332 hasConceptScore W3148879332C71924100 @default.
- W3148879332 hasConceptScore W3148879332C86803240 @default.
- W3148879332 hasOpenAccess W3148879332 @default.
- W3148879332 hasRelatedWork W1639880497 @default.
- W3148879332 hasRelatedWork W1965576720 @default.
- W3148879332 hasRelatedWork W1996396440 @default.
- W3148879332 hasRelatedWork W2014275838 @default.
- W3148879332 hasRelatedWork W2022369601 @default.
- W3148879332 hasRelatedWork W2025573337 @default.
- W3148879332 hasRelatedWork W2039143344 @default.
- W3148879332 hasRelatedWork W2074428232 @default.
- W3148879332 hasRelatedWork W2151935873 @default.
- W3148879332 hasRelatedWork W2296701010 @default.
- W3148879332 hasRelatedWork W2297840043 @default.
- W3148879332 hasRelatedWork W2351715520 @default.
- W3148879332 hasRelatedWork W2377148838 @default.
- W3148879332 hasRelatedWork W2407067750 @default.
- W3148879332 hasRelatedWork W2460720847 @default.
- W3148879332 hasRelatedWork W2569255654 @default.
- W3148879332 hasRelatedWork W3011957926 @default.
- W3148879332 hasRelatedWork W3030654590 @default.
- W3148879332 hasRelatedWork W3044988967 @default.
- W3148879332 hasRelatedWork W3118393476 @default.
- W3148879332 isParatext "false" @default.
- W3148879332 isRetracted "false" @default.
- W3148879332 magId "3148879332" @default.
- W3148879332 workType "article" @default.