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- W3148886272 abstract "Objective To investigate the changes in the expression of nuclear receptor subfamily1(Nr1d1) in the lungs of rats with ventilation- induced lung injury and explore the molecular mechanism. Methods Seventy- two rats were randomly divided into 4 groups for observation at 4 time points(1:00 AM, 7:00 AM, 1:00 PM and 7:00 PM), and each group was further divided into 3 subgroups(Group FB, Group LV and Group HV). After ventilation for 3 h, the rats were sacrificed and lung tissue samples were obtained for testing the expression of Nr1d1 using gene chip technology and RT-PCR. Results Nr1d1 gene expression was down- regulated in HV group as shown by gene chip RT- PCR data. Cosine analysis showed that Nr1d1expression exhibited a rhythmicity in FB group(P0.05). Conclusion The rhythmicity of Nr1d1 expression disappears as the tidal volume the increase. Diminished Nr1d1 expression is closely correlated with ventilation-induced lung injury in rats." @default.
- W3148886272 created "2021-04-13" @default.
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- W3148886272 date "2013-01-01" @default.
- W3148886272 modified "2023-09-28" @default.
- W3148886272 title "Pulmonary expression of Nr1d1 in rats with ventilation-induced lung injury" @default.
- W3148886272 hasPublicationYear "2013" @default.
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