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- W3148921815 abstract "在对 Klebsiella pneumoniae 的嗜中性的反应的 cytokines 表示上探索 cefodizime 的调整效果的目的(Kle。p ) 治疗。我们检测了 cytokines 的类型和表达式的方法由 cDNA 数组和 RT-PCR 由 neutrophils 藏匿了。我们也由检测象受体 4 一样的使用费(TLR4 ) 的表达式在这进程分析了信号 transduction 的变化， B (I-B ) 的禁止者因素由 neutrophils 表示了。在 neutrophils DNA 有约束力的 NF-B 的活动被 electrophoretic 活动性移动试金(EMSA ) 测量。结果 Cefodizime 在 Kle 的早阶段增加了 TNF- ， IL-1 和 TLR4 的 mRNA 表示的 neutrophils 生产。在老鼠的 p 刺激，它似乎是相应于提高的 NF-B DNA 有约束力的活动。结论 Cefodizime 由与 Kle 的挑战在老鼠影响 TLR4 mRNA 的表示和 NF-B 的 DNA 有约束力的活动通过 LPS-TLR4-NF-B 小径调整 neutrophils 的 cytokines 表示。p。" @default.
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- W3148921815 date "2008-01-01" @default.
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- W3148921815 title "Effect of cefodizime on cytokines expression in mouse neutrophils and its related mechanism" @default.
- W3148921815 hasPublicationYear "2008" @default.
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